10-10013

antibody from ABEOMICS Inc.
Targeting: MYC bHLHe39, c-Myc, MYCC
Provider product page for 10-10013

Antibody data

Product number
10-10013 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-c-MYC Antibody
Antibody type
Monoclonal
Description
c-Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. The Myc protein activates transcription as part of a heteromeric complex with Max. Myc protein represses the expression of Ferritin-H, which sequesters intracellular iron, and stimulates the expression of IRP2 (Iron Regulatory Protein-2), which increases the intracellular iron pool. Myc induces transcription of the E2F1, E2F2 and E2F3 genes. Myc-induced S phase and apoptosis requires distinct E2F activities. The induction of specific E2F activities is an essential component in the Myc pathways that control cell proliferation and cell fate decisions.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A synthetic peptide corresponding t
o amino acids 408-432 (AEEQKLISEEDL
LRKRREQLKHKLE) of human c-Myc was u
sed as the immunogen for this antib
ody.
Isotype
IgG
Antibody clone number
9 E 10
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
MYC protein structure - 10-10013 shown in red.