GTX103436

Seira N, Yamagata K, Fukushima K, Araki Y, Kurata N, Yanagisawa N, Mashimo M, Nakamura H, Regan JW, Murayama T, Fujino H
Pharmacology research & perspectives 2018 Dec;6(6):e00441

Differential Roles of Glycogen Synthase Kinase 3 Subtypes Alpha and Beta in Cortical Development.

Ma YX, Wang XL, Chen JQ, Li B, Hur EM, Saijilafu
Frontiers in molecular neuroscience 2017;10:391

Hsp90α Mediates BMI1 Expression in Breast Cancer Stem/Progenitor Cells through Facilitating Nuclear Translocation of c-Myc and EZH2.

Lee YC, Chang WW, Chen YY, Tsai YH, Chou YH, Tseng HC, Chen HL, Wu CC, Chang-Chien J, Lee HT, Yang HF, Wang BY
International journal of molecular sciences 2017 Sep 15;18(9)

Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets.

Lin HC, Lin MH, Liao JH, Wu TH, Lee TH, Mi FL, Wu CH, Chen KC, Cheng CH, Lin CW
Journal of agricultural and food chemistry 2017 Jan 11;65(1):51-59

Nuclear PKM2 expression, an independent risk factor for ER after curative resection of hepatocellular carcinoma.

Fan F, Wu H, Liu Z, Hou X, Chen W, Wang A, Lu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1858-1864

ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance.

Chung IH, Liu H, Lin YH, Chi HC, Huang YH, Yang CC, Yeh CT, Tan BC, Lin KH
Oncotarget 2016 Apr 19;7(16):22448-59

Macrophage Infiltration Induces Gastric Cancer Invasiveness by Activating the β-Catenin Pathway.

Wu MH, Lee WJ, Hua KT, Kuo ML, Lin MT
PloS one 2015;10(7):e0134122

FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis.

Fu Y, Lin Y, Yang Z, Yang G, Li G, Liu Y, Tan X, Huang Y, Wu X, Wang Y, Xiong H, Zhang M, Fang L, Ge Y, Zeng J, Cai Y, Bai J, Wu S
Medical oncology (Northwood, London, England) 2015 Aug;32(8):215

Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87.

Huang CC, Wu DW, Lin PL, Lee H
Oncotarget 2015 Apr 20;6(11):8698-708

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Supportive validation

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Main image
Experimental details: Sample (30 ?g of whole cell lysate)? ? A: NIH-3T3 ? B: Raw264.7 ? 10% SDS PAGE? ? GTX103436 diluted at 1:1000 ? ? The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Sample (whole cell lysate) A: 293T 20ug B: 293T 10ug 10% SDS PAGE GTX103436 diluted at 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: c-Myc antibody detects c-Myc protein by western blot analysis. HeLa whole cell extracts and nuclear extracts (30 ?g) were separated by 7.5% SDS-PAGE, and the membrane was blotted with c-Myc antibody (GTX103436) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Wild-type (WT) and c-Myc knockout (KO) 293T cell extracts (30 ?g) were separated by 10% SDS-PAGE, and the membrane was blotted with c-Myc antibody (GTX103436) diluted at 1:2000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: c-Myc antibody detects c-Myc protein at nucleus by immunofluorescent analysis.Sample: NT2D1 cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: c-Myc protein stained by c-Myc antibody (GTX103436) diluted at 1:200.Blue: Hoechst 33342 staining.Scale bar = 10 £gm.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: c-Myc antibody immunoprecipitates c-Myc protein in IP experiments. IP Sample: 1000 £gg 293T whole cell lysate/extract A. 20 £gg 293T whole cell lysate/extract B. Control with 2.5 £gg of preimmune rabbit IgG C. Immunoprecipitation of c-Myc protein by 2.5 £gg of c-Myc antibody (GTX103436) 10% SDS-PAGE The immunoprecipitated c-Myc protein was detected by c-Myc antibody (GTX103436) diluted at 1:1000. EasyBlot anti-rabbit IgG (GTX221666-01) was used as a secondary reagent.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: c-Myc antibody immunoprecipitates c-Myc protein-DNA in ChIP experiments. ChIP Sample: 293T whole cell lysate/extract A. 5 £gg preimmune rabbit IgG B. 5 £gg of c-Myc antibody (GTX103436) The precipitated DNA was detected by PCR with primer set targeting to mSHMT promoter.