PANK1

This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]

Description

Pantothenate kinase 1

Tissue specificity

Tissue enhanced (kidney, liver)

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (89579497 - 89645572)

Ensembl ID

ENSG00000152782  (ver. 103.38)

Orthologs

Mouse Pank1: ENSMUSG00000033610

UniProt

Q8TE04

neXtProt

NX_Q8TE04

Human splice variants
Mouse splice variants

Protein structure