INSL3

This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Description

Insulin like 3

Tissue specificity

Tissue enriched (testis)

Predicted location

Secreted to blood

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

19 (17816512 - 17821574)

Ensembl ID

ENSG00000248099  (ver. 103.38)

Orthologs

-

UniProt

P51460

neXtProt

NX_P51460

Human splice variants

Protein structure