CRP

The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020]

Description

C-reactive protein

Tissue specificity

Tissue enriched (liver)

Subcell location

Nucleoplasm, Vesicles, Intermediate filaments

Predicted location

Intracellular, Secreted to blood

Protein family

Cancer-related genes
Candidate cardiovascular disease genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (159712289 - 159714589)

Ensembl ID

ENSG00000132693  (ver. 103.38)

Orthologs

Mouse Crp: ENSMUSG00000037942

UniProt

P02741

neXtProt

NX_P02741

Human splice variants
Mouse splice variants

Protein structure