BS7862

antibody from Bioworld Technology, Inc
Targeting: BAG5
Provider product page for BS7862
Western blot
Immunohistochemistry

Antibody data

Product number
BS7862 - Provider product page
Provider
Bioworld Technology, Inc
Product name
BAG5 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human BAG5.
Description
Bag-5 (Bcl-2-associated athanogene 5), also known as Bag family molecular chaperone regulator 5, is a member of the Bag family of proteins and contains four Bag domains. Via their Bag domain, Bag proteins bind with high affinity to the HSC 70/HSP 70 ATPase domain, regulating chaperone activity and apoptosis. Bag-5 is a component of the HSP 70/Parkin complex and acts to inhibit Parkin E3 ubiquitin ligase activity and HSP 70 chaperone activity. In this complex, Bag-5 directly interacts with the ATPase domain of HSP 70 and the N-terminal linker region of Parkin. Bag-5 expression is induced upon dopaminergic neuron injury and functions to sensitize the neurons to injuryinduced cell death. In addition, Bag-5 may be a useful target in therapies for neurodegenerative diseases such as Parkinson£ªs disease which is caused by a mutation in the gene encoding Parkin.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BAG5 protein structure - BS7862 shown in red.