CDKN2B

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Description

Cyclin dependent kinase inhibitor 2B

Tissue specificity

Tissue enhanced (esophagus, intestine)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

9 (22002903 - 22009305)

Ensembl ID

ENSG00000147883  (ver. 103.38)

Orthologs

Mouse Cdkn2b: ENSMUSG00000073802

UniProt

P42772

neXtProt

NX_P42772

Human splice variants
Mouse splice variants

Protein structure