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Learn10883-1-AP
antibody from Proteintech Group
Targeting: CDKN2A
ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf
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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [190]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 10883-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10883-1-AP, RRID:AB_2078303
- Product name
- P16-INK4A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated P16-INK4A antibody (Cat. #10883-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cell homeostasis.
An in vitro senescence model of gingival epithelial cell induced by hydrogen peroxide treatment.
PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair.
Statins Mitigate Stress-Related Vascular Aging and Atherosclerosis in apoE-Deficient Mice Fed High Fat-Diet: The Role of Glucagon-Like Peptide-1/Adiponectin Axis.
PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway.
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway.
One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence.
Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function.
TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer.
IL-21 Is an Accomplice of PD-L1 in the Induction of PD-1-Dependent Treg Generation in Head and Neck Cancer.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice.
NFATc4 mediates ethanol-triggered hepatocyte senescence.
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway.
Ubiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3.
Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease.
Dipeptidyl peptidase-4 inhibition prevents lung injury in mice under chronic stress via the modulation of oxidative stress and inflammation.
Muse Cells Have Higher Stress Tolerance than Adipose Stem Cells due to the Overexpression of the CCNA2 Gene.
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury.
Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice.
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Bmi-1 alleviates adventitial fibroblast senescence by eliminating ROS in pulmonary hypertension.
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway.
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.
Baicalein Delays H2O2-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.
Targeting senescent cells improves functional recovery after spinal cord injury.
Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy.
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
Irradiation Accelerates Plaque Formation and Cellular Senescence in Flow-Altered Carotid Arteries of Apolipoprotein E Knock-Out Mice.
Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes.
CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent manner.
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome.
Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence-associated secretory phenotype.
Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma.
Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer.
eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα+ mesenchymal progenitors.
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
The Extracellular Metabolome Stratifies Low and High Risk Potentially Premalignant Oral Keratinocytes and Identifies Citrate as a Potential Non-Invasive Marker of Tumour Progression.
Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy.
HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress.
Extracts of Jasminum sambac flowers fermented by Lactobacillus rhamnosus inhibit H2 O2 - and UVB-induced aging in human dermal fibroblasts.
miR-127-3p Is an Epigenetic Activator of Myofibroblast Senescence Situated within the MicroRNA-Enriched Dlk1-Dio3‒Imprinted Domain on Mouse Chromosome 12.
Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells.
Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process.
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.
CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels.
Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation.
Piwi-interacting RNAs play a role in vitamin C-mediated effects on endothelial aging.
Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.
High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis.
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding.
TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs.
Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence.
Paclitaxel exposure downregulates miR-522 expression and its downregulation induces paclitaxel resistance in ovarian cancer cells.
Metformin promotes the osseointegration of titanium implants under osteoporotic conditions by regulating BMSCs autophagy, and osteogenic differentiation.
HO-1 overexpression alleviates senescence by inducing autophagy via the mitochondrial route in human nucleus pulposus cells.
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.
A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.
PAI-1 Regulation of TGF-β1-induced Alveolar Type II Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages.
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics.
Nrf2 modulates immunosuppressive ability and cellular senescence of human umbilical cord mesenchymal stem cells.
Senolytic CAR T cells reverse senescence-associated pathologies.
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A.
Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1 - CD44 axis.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR.
Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.
Acetyl-11-keto-β-boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular carcinoma cells in vitro and in vivo.
Role and mechanism of FLNa and UCP2 in the development of cervical cancer.
Increased production of functional small extracellular vesicles in senescent endothelial cells.
A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.
Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer.
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.
NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling.
New Insights into Chronological Mobility of Retrotransposons In Vivo.
Overexpression of P16 reversed the MDR1-mediated DDP resistance in the cervical adenocarcinoma by activating the ERK1/2 signaling pathway.
Interferon Regulatory Factor 3 Deficiency Induces Age-Related Alterations of the Retina in Young and Old Mice.
P16 Methylation Leads to Paclitaxel Resistance of Advanced Non-Small Cell Lung Cancer.
Inhibition of polycomb repressor complex 2 ameliorates neointimal hyperplasia by suppressing trimethylation of H3K27 in vascular smooth muscle cells.
Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence.
Tumor necrosis factor-inducible gene 6 reprograms hepatic stellate cells into stem-like cells, which ameliorates liver damage in mouse.
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.
Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging.
The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence.
Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways.
Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways.
Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability.
Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis.
MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1.
Fra-1 plays a critical role in angiotensin II-induced vascular senescence.
The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway.
Correlation of p16 and nm23-H1 expression levels with incidence and prognosis of soft tissue sarcoma.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells.
Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer.
Cathepsin S Deficiency Mitigated Chronic Stress-Related Neointimal Hyperplasia in Mice.
Aberrant methylation-induced dysfunction of p16 is associated with osteoblast activation caused by fluoride.
S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α.
lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs.
Phenotypic and functional differences between senescent and aged murine microglia.
Shuttling SLC2A4RG is regulated by 14-3-3θ to modulate cell survival via caspase-3 and caspase-6 in human glioma.
p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation.
A basal-enriched microRNA is required for prostate tumorigenesis in a Pten knockout mouse model.
Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway.
Roles of p38α and p38β mitogen‑activated protein kinase isoforms in human malignant melanoma A375 cells.
Releasing Behavior of Lipopolysaccharide from Gelatin Modulates Inflammation, Cellular Senescence, and Bone Formation in Critical-Sized Bone Defects in Rat Calvaria.
Dipeptidyl peptidase-4 inhibition prevents vascular aging in mice under chronic stress: Modulation of oxidative stress and inflammation.
Senescence caused by inactivation of the homeodomain transcription factor Pdx1 in adult pancreatic acinar cells in mice.
Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells.
MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages.
PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.
Stem cell competition orchestrates skin homeostasis and ageing.
Histone Deacetylation in the Promoter of p16 Is Involved in Fluoride-Induced Human Osteoblast Activation via the Inhibition of Sp1 Binding.
Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo.
A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal.
Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production.
NRF2-regulated cell cycle arrest at early stage of oxidative stress response mechanism.
Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence.
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma.
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Comparative characterization of SHED and DPSCs during extended cultivation in vitro.
Counteracting survival functions of EBNA3C in Epstein-Barr virus (EBV)-driven lymphoproliferative diseases by combination of SAHA and bortezomib.
Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.
Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis.
Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer.
Identification of early indicators of altered metabolism in normal development using a rodent model system.
Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice.
Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells.
Overexpression of PP1-NIPP1 limits the capacity of cells to repair DNA double-strand breaks.
Atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats through a mechanism involving down-regulation of miR-21-5p/203a-3p.
Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma.
EZH2 inhibition sensitizes tamoxifen‑resistant breast cancer cells through cell cycle regulation.
Young plasma reverses age-dependent alterations in hepatic function through the restoration of autophagy.
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1.
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.
H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing.
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation
Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress.
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.
5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1.
Potency of Human Cardiosphere-Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability.
A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis.
Activation of Wnt/β-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging.
miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1.
Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8.
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
Knockout of 4.1B triggers malignant transformation in SV40T-immortalized mouse embryo fibroblast cells.
MicroRNA let-7g inhibited hypoxia-induced proliferation of PASMCs via G0/G1 cell cycle arrest by targeting c-myc.
Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent.
Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.
Long-term effects of repeated superovulation on the uterus and mammary gland in rhesus monkeys.
N-Stearoyl-L-Tyrosine Inhibits the Senescence of Neural Stem/Progenitor Cells Induced by Aβ 1-42 via the CB2 Receptor.
Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D-Galactose.
Inhibition of BMI1 induces autophagy-mediated necroptosis.
Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response.
Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation.
miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.
The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity.
Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes.
Comparison of liver oncogenic potential among human RAS isoforms.
Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis.
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.
Lentivirus-mediated gene silencing of NOB1 suppresses non-small cell lung cancer cell proliferation.
Evaluation of Protein Profiles From Treated Xenograft Tumor Models Identifies an Antibody Panel for Formalin-fixed and Paraffin-embedded (FFPE) Tissue Analysis by Reverse Phase Protein Arrays (RPPA).
Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction.
Cathepsin K knockout alleviates aging-induced cardiac dysfunction.
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies.
Potent effects of dioscin against liver fibrosis.
Fullerenol protects retinal pigment epithelial cells from oxidative stress-induced premature senescence via activating SIRT1.
BCL6 overexpression is associated with decreased p19 ARF expression and confers an independent prognosticator in gallbladder carcinoma.
Ocular expression and distribution of products of the POAG-associated chromosome 9p21 gene region.
Teng-Long-Bu-Zhong-Tang, a Chinese herbal formula, enhances anticancer effects of 5--Fluorouracil in CT26 colon carcinoma.
Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells.
Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.
Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells.
Correlation of MTS1/p16 and nm23 mRNA expression with survival in patients with peripheral synovial sarcoma.
Alves LS, Marques ARA, Padrão N, Carvalho FA, Ramalho J, Lopes CS, Soares MIL, Futter CE, Pinho E Melo TMVD, Santos NC, Vieira OV
Journal of cell science 2022 Mar 1;135(5)
Journal of cell science 2022 Mar 1;135(5)
An in vitro senescence model of gingival epithelial cell induced by hydrogen peroxide treatment.
Giri S, Takada A, Paudel D, Yoshida K, Furukawa M, Kuramitsu Y, Matsushita K, Abiko Y, Furuichi Y
Odontology 2022 Jan;110(1):44-53
Odontology 2022 Jan;110(1):44-53
PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair.
Wang Y, Sui Y, Lian A, Han X, Liu F, Zuo K, Liu M, Sun W, Wang Z, Liu Z, Zou F, Lu R, Jin M, Du H, Xu K, Liu X, Liu J
Frontiers in cell and developmental biology 2021;9:739868
Frontiers in cell and developmental biology 2021;9:739868
Statins Mitigate Stress-Related Vascular Aging and Atherosclerosis in apoE-Deficient Mice Fed High Fat-Diet: The Role of Glucagon-Like Peptide-1/Adiponectin Axis.
Lei Y, Cui Q, Yang G, Piao L, Inoue A, Wu H, Li X, Kuzuya M, Cheng XW
Frontiers in cell and developmental biology 2021;9:687868
Frontiers in cell and developmental biology 2021;9:687868
PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway.
Zhang Y, Lv Z, Liu Y, Cao H, Yang J, Wang B
Oxidative medicine and cellular longevity 2021;2021:9980444
Oxidative medicine and cellular longevity 2021;2021:9980444
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway.
Zhang S, Zhang R, Qiao P, Ma X, Lu R, Wang F, Li C, E L, Liu H
Stem cells international 2021;2021:6616240
Stem cells international 2021;2021:6616240
One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence.
Qing Y, Li H, Zhao Y, Hu P, Wang X, Yu X, Zhu M, Wang H, Wang Z, Guo Q, Hui H
Oxidative medicine and cellular longevity 2021;2021:5529518
Oxidative medicine and cellular longevity 2021;2021:5529518
Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function.
Palmer A, Epton S, Crawley E, Straface M, Gammon L, Edgar MM, Xu Y, Elahi S, Chin-Aleong J, Martin JE, Bishop CL, Knowles CH, Sanger GJ
Frontiers in neuroscience 2021;15:747067
Frontiers in neuroscience 2021;15:747067
TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer.
Zhang D, Lu P, Zhu K, Wu H, Dai Y
Frontiers in oncology 2021;11:724437
Frontiers in oncology 2021;11:724437
IL-21 Is an Accomplice of PD-L1 in the Induction of PD-1-Dependent Treg Generation in Head and Neck Cancer.
Zhao Y, Zhang Z, Lei W, Wei Y, Ma R, Wen Y, Wei F, Fan J, Xu Y, Chen L, Lyu K, Lin H, Wen W, Sun W
Frontiers in oncology 2021;11:648293
Frontiers in oncology 2021;11:648293
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice.
Wang H, Muthu Karuppan MK, Devadoss D, Nair M, Chand HS, Lakshmana MK
Neurobiology of aging 2021 Oct;106:26-36
Neurobiology of aging 2021 Oct;106:26-36
NFATc4 mediates ethanol-triggered hepatocyte senescence.
Wu R, Wang X, Shao Y, Jiang Y, Zhou Y, Lu C
Toxicology letters 2021 Oct 10;350:10-21
Toxicology letters 2021 Oct 10;350:10-21
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway.
Zhang L, Liu M, Liu W, Hu C, Li H, Deng J, Cao Q, Wang Y, Hu W, Li Q
Laboratory investigation; a journal of technical methods and pathology 2021 Nov;101(11):1418-1426
Laboratory investigation; a journal of technical methods and pathology 2021 Nov;101(11):1418-1426
Ubiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3.
Zhou Q, Wang W, Wu J, Qiu S, Yuan S, Fu PL, Qian QR, Xu YZ
Bioengineered 2021 Nov 30;
Bioengineered 2021 Nov 30;
Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease.
Zhang J, Gao F, Ma Y, Xue T, Shen Y
iScience 2021 Nov 19;24(11):103327
iScience 2021 Nov 19;24(11):103327
Dipeptidyl peptidase-4 inhibition prevents lung injury in mice under chronic stress via the modulation of oxidative stress and inflammation.
Zhang S, Li P, Xin M, Jin X, Zhao L, Nan Y, Cheng XW
Experimental animals 2021 Nov 10;70(4):541-552
Experimental animals 2021 Nov 10;70(4):541-552
Muse Cells Have Higher Stress Tolerance than Adipose Stem Cells due to the Overexpression of the CCNA2 Gene.
Wang P, Wang S, Ji F, Zhang R
Stem cells and development 2021 Nov 1;30(21):1056-1069
Stem cells and development 2021 Nov 1;30(21):1056-1069
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury.
Uryga AK, Grootaert MOJ, Garrido AM, Oc S, Foote K, Chappell J, Finigan A, Rossiello F, d'Adda di Fagagna F, Aravani D, Jorgensen HF, Bennett MR
Communications biology 2021 May 21;4(1):611
Communications biology 2021 May 21;4(1):611
Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice.
Jia X, Sun B, Tu Q, Qi H, Li L, Liu X, Yan L, Dai H, Kong Q, Tang C, Zhao X
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2021 Mar;21(2):418-427
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2021 Mar;21(2):418-427
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Zhong H, Zhou Z, Guo L, Liu F, Zheng B, Bi S, Tian C
Mechanisms of ageing and development 2021 Mar;194:111417
Mechanisms of ageing and development 2021 Mar;194:111417
Bmi-1 alleviates adventitial fibroblast senescence by eliminating ROS in pulmonary hypertension.
Li K, Li Y, Yu Y, Ding J, Huang H, Chu C, Hu L, Yu Y, Cao Y, Xu P, Fulton D, Chen F
BMC pulmonary medicine 2021 Mar 5;21(1):80
BMC pulmonary medicine 2021 Mar 5;21(1):80
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Shao Y, Zhao C, Pan J, Zeng C, Zhang H, Liu L, Fan K, Liu X, Luo B, Fang H, Bai X, Zhang H, Cai D
Aging 2021 Mar 19;13(7):9646-9664
Aging 2021 Mar 19;13(7):9646-9664
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway.
Wang F, Luo Y, Zhang L, Younis M, Yuan L
Cancer gene therapy 2021 Mar 11;
Cancer gene therapy 2021 Mar 11;
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.
Jia R, Yang F, Yan P, Ma L, Yang L, Li L
Free radical biology & medicine 2021 Jun;169:158-168
Free radical biology & medicine 2021 Jun;169:158-168
Baicalein Delays H2O2-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.
Gao L, Zheng WG, Wu XK, Du GH, Qin XM
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335
Targeting senescent cells improves functional recovery after spinal cord injury.
Paramos-de-Carvalho D, Martins I, Cristóvão AM, Dias AF, Neves-Silva D, Pereira T, Chapela D, Farinho A, Jacinto A, Saúde L
Cell reports 2021 Jul 6;36(1):109334
Cell reports 2021 Jul 6;36(1):109334
Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy.
Liu J, He J, Ge L, Xiao H, Huang Y, Zeng L, Jiang Z, Lu M, Hu Z
Stem cell research & therapy 2021 Jul 22;12(1):413
Stem cell research & therapy 2021 Jul 22;12(1):413
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
Li P, Liu X, Zhao T, Li F, Wang Q, Zhang P, Hirayama R, Chen W, Jin X, Zheng X, Wang Z, Li Q
Cell death discovery 2021 Jul 20;7(1):184
Cell death discovery 2021 Jul 20;7(1):184
Irradiation Accelerates Plaque Formation and Cellular Senescence in Flow-Altered Carotid Arteries of Apolipoprotein E Knock-Out Mice.
Yamamoto Y, Minami M, Yoshida K, Nagata M, Miyata T, Yang T, Takayama N, Suzuki K, Okawa M, Yamada K, Miyamoto S
Journal of the American Heart Association 2021 Jul 20;10(14):e020712
Journal of the American Heart Association 2021 Jul 20;10(14):e020712
Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes.
Sun X, Fu P, Xie L, Chai S, Xu Q, Zeng L, Wang X, Jiang N, Sang M
International journal of molecular medicine 2021 Jan;47(1):335-345
International journal of molecular medicine 2021 Jan;47(1):335-345
CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent manner.
Chen YC, Hsieh HH, Chang HC, Wang HC, Lin WJ, Lin JJ
The Journal of biological chemistry 2021 Jan-Jun;296:100564
The Journal of biological chemistry 2021 Jan-Jun;296:100564
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
Wang L, Xu L, Wang Y
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome.
Kang SM, Yoon MH, Ahn J, Kim JE, Kim SY, Kang SY, Joo J, Park S, Cho JH, Woo TG, Oh AY, Chung KJ, An SY, Hwang TS, Lee SY, Kim JS, Ha NC, Song GY, Park BJ
Communications biology 2021 Jan 4;4(1):5
Communications biology 2021 Jan 4;4(1):5
Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence-associated secretory phenotype.
Wallis R, Josipovic N, Mizen H, Robles-Tenorio A, Tyler EJ, Papantonis A, Bishop CL
Journal of extracellular vesicles 2021 Feb;10(4):e12041
Journal of extracellular vesicles 2021 Feb;10(4):e12041
Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma.
Chen T, Liu L, Zou Y, Hu X, Zhang W, Zhou T, Luo X, Fu W, Xu J
Cancer biology & medicine 2021 Feb 15;18(1):227-244
Cancer biology & medicine 2021 Feb 15;18(1):227-244
Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer.
Gao Q, Wu Y, Lu C, Kai W, Xie W, Wang Q, Wang L, Liu S, Pan Y
Cell cycle (Georgetown, Tex.) 2021 Dec;20(23):2465-2475
Cell cycle (Georgetown, Tex.) 2021 Dec;20(23):2465-2475
eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
Chen YX, Wang CJ, Xiao DS, He BM, Li M, Yi XP, Zhang W, Yin JY, Liu ZQ
Pharmacological research 2021 Dec;174:105934
Pharmacological research 2021 Dec;174:105934
Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα+ mesenchymal progenitors.
Shang GK, Han L, Wang ZH, Song M, Wang D, Tan YM, Li YH, Li YL, Zhang W, Zhong M
Journal of cachexia, sarcopenia and muscle 2021 Dec;12(6):1741-1756
Journal of cachexia, sarcopenia and muscle 2021 Dec;12(6):1741-1756
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo WT, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM Jr, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E
Science (New York, N.Y.) 2021 Dec 10;374(6573):eabk0410
Science (New York, N.Y.) 2021 Dec 10;374(6573):eabk0410
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
Liao X, Wu C, Shao Z, Zhang S, Zou Y, Wang K, Ha Y, Xing J, Zheng A, Shen Z, Zheng S, Guo J, Jie W
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
The Extracellular Metabolome Stratifies Low and High Risk Potentially Premalignant Oral Keratinocytes and Identifies Citrate as a Potential Non-Invasive Marker of Tumour Progression.
Karen-Ng LP, James EL, Stephen A, Bennett MH, Mycielska ME, Parkinson EK
Cancers 2021 Aug 21;13(16)
Cancers 2021 Aug 21;13(16)
Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy.
Jiang Y, Zhou Y, Xu W, Wang X, Jin H, Bao X, Lu C
Cell biology and toxicology 2021 Aug 17;
Cell biology and toxicology 2021 Aug 17;
HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress.
Thangaraj A, Chivero ET, Tripathi A, Singh S, Niu F, Guo ML, Pillai P, Periyasamy P, Buch S
Redox biology 2021 Apr;40:101843
Redox biology 2021 Apr;40:101843
Extracts of Jasminum sambac flowers fermented by Lactobacillus rhamnosus inhibit H2 O2 - and UVB-induced aging in human dermal fibroblasts.
Ho CC, Ng SC, Chuang HL, Wen SY, Kuo CH, Mahalakshmi B, Huang CY, Kuo WW
Environmental toxicology 2021 Apr;36(4):607-619
Environmental toxicology 2021 Apr;36(4):607-619
miR-127-3p Is an Epigenetic Activator of Myofibroblast Senescence Situated within the MicroRNA-Enriched Dlk1-Dio3‒Imprinted Domain on Mouse Chromosome 12.
Auler M, Bergmeier V, Georgieva VS, Pitzler L, Frie C, Nüchel J, Eckes B, Hinz B, Brachvogel B
The Journal of investigative dermatology 2021 Apr;141(4S):1076-1086.e3
The Journal of investigative dermatology 2021 Apr;141(4S):1076-1086.e3
Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells.
Chen CC, Chen J, Wang WL, Xie L, Shao CQ, Zhang YX
Orthopaedic surgery 2021 Apr;13(2):583-591
Orthopaedic surgery 2021 Apr;13(2):583-591
Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process.
Tan YZ, Xu XY, Dai JM, Yin Y, He XT, Zhang YL, Zhu TX, An Y, Tian BM, Chen FM
Stem cell research & therapy 2021 Apr 29;12(1):254
Stem cell research & therapy 2021 Apr 29;12(1):254
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.
Kang SM, Yoon MH, Lee SJ, Ahn J, Yi SA, Nam KH, Park S, Woo TG, Cho JH, Lee J, Ha NC, Park BJ
Scientific reports 2021 Apr 27;11(1):9122
Scientific reports 2021 Apr 27;11(1):9122
CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels.
Lv F, Li N, Kong M, Wu J, Fan Z, Miao D, Xu Y, Ye Q, Wang Y
Frontiers in cell and developmental biology 2020;8:176
Frontiers in cell and developmental biology 2020;8:176
Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation.
Feng H, Mou SQ, Li WJ, Zhang N, Zhou ZY, Ding W, Bian ZY, Liao HH
Oxidative medicine and cellular longevity 2020;2020:2647807
Oxidative medicine and cellular longevity 2020;2020:2647807
Piwi-interacting RNAs play a role in vitamin C-mediated effects on endothelial aging.
Zheng S, Zheng H, Huang A, Mai L, Huang X, Hu Y, Huang Y
International journal of medical sciences 2020;17(7):946-952
International journal of medical sciences 2020;17(7):946-952
Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.
Stojanović SD, Fuchs M, Kunz M, Xiao K, Just A, Pich A, Bauersachs J, Fiedler J, Sedding D, Thum T
Frontiers in physiology 2020;11:520
Frontiers in physiology 2020;11:520
High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis.
Maique J, Flores B, Shi M, Shepard S, Zhou Z, Yan S, Moe OW, Hu MC
Frontiers in pharmacology 2020;11:1273
Frontiers in pharmacology 2020;11:1273
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Zou G, Zhang X, Wang L, Li X, Xie T, Zhao J, Yan J, Wang L, Ye H, Jiao S, Xiang R, Shi Y
Theranostics 2020;10(15):6839-6853
Theranostics 2020;10(15):6839-6853
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding.
Wang X, Li D, Wu H, Liu F, Liu F, Zhang Q, Li J
Mechanisms of ageing and development 2020 Sep;190:111293
Mechanisms of ageing and development 2020 Sep;190:111293
TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs.
Foster DJ, Chang HM, Haswell JR, Gregory RI, Slack FJ
Cell cycle (Georgetown, Tex.) 2020 Sep;19(18):2314-2326
Cell cycle (Georgetown, Tex.) 2020 Sep;19(18):2314-2326
Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence.
Wang B, Liu F, Liu Z, Han X, Lian A, Zhang Y, Zuo K, Wang Y, Liu M, Zou F, Jiang Y, Jin M, Liu X, Liu J
Biotechnology letters 2020 Oct;42(10):1877-1885
Biotechnology letters 2020 Oct;42(10):1877-1885
Paclitaxel exposure downregulates miR-522 expression and its downregulation induces paclitaxel resistance in ovarian cancer cells.
Miyamoto M, Sawada K, Nakamura K, Yoshimura A, Ishida K, Kobayashi M, Shimizu A, Yamamoto M, Kodama M, Hashimoto K, Kimura T
Scientific reports 2020 Oct 7;10(1):16755
Scientific reports 2020 Oct 7;10(1):16755
Metformin promotes the osseointegration of titanium implants under osteoporotic conditions by regulating BMSCs autophagy, and osteogenic differentiation.
Lin J, Xu R, Shen X, Jiang H, Du S
Biochemical and biophysical research communications 2020 Oct 15;531(2):228-235
Biochemical and biophysical research communications 2020 Oct 15;531(2):228-235
HO-1 overexpression alleviates senescence by inducing autophagy via the mitochondrial route in human nucleus pulposus cells.
Yi W, Lan H, Wen Y, Wang Y, He D, Bai Z, Zhang Y, Jiang W, Liu B, Shen J, Hu Z
Journal of cellular physiology 2020 Nov;235(11):8402-8415
Journal of cellular physiology 2020 Nov;235(11):8402-8415
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.
Wang L, Chen R, Li G, Wang Z, Liu J, Liang Y, Liu JP
Cell metabolism 2020 Nov 3;32(5):860-877.e9
Cell metabolism 2020 Nov 3;32(5):860-877.e9
A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.
Jia Y, Jin H, Gao L, Yang X, Wang F, Ding H, Chen A, Tan S, Zhang F, Shao J, Wang S, Zheng S
Journal of cellular and molecular medicine 2020 May;24(9):5304-5316
Journal of cellular and molecular medicine 2020 May;24(9):5304-5316
PAI-1 Regulation of TGF-β1-induced Alveolar Type II Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages.
Rana T, Jiang C, Liu G, Miyata T, Antony V, Thannickal VJ, Liu RM
American journal of respiratory cell and molecular biology 2020 Mar;62(3):319-330
American journal of respiratory cell and molecular biology 2020 Mar;62(3):319-330
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Dao R, Wudu M, Hui L, Jiang J, Xu Y, Ren H, Qiu X
Pathology, research and practice 2020 Mar;216(3):152823
Pathology, research and practice 2020 Mar;216(3):152823
Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics.
Honda Y, Huang A, Tanaka T, Han X, Gao B, Liu H, Wang X, Zhao J, Hashimoto Y, Yamamoto K, Matsumoto N, Baba S, Umeda M
International journal of molecular sciences 2020 Jun 13;21(12)
International journal of molecular sciences 2020 Jun 13;21(12)
Nrf2 modulates immunosuppressive ability and cellular senescence of human umbilical cord mesenchymal stem cells.
Jie Z, Huan Y, Mengyun W, Yasha L, Huafeng P, Ke Y
Biochemical and biophysical research communications 2020 Jun 11;526(4):1021-1027
Biochemical and biophysical research communications 2020 Jun 11;526(4):1021-1027
Senolytic CAR T cells reverse senescence-associated pathologies.
Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman SL, Ponomarev V, Piersigilli A, Sadelain M, Lowe SW
Nature 2020 Jul;583(7814):127-132
Nature 2020 Jul;583(7814):127-132
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A.
Göbl C, Morris VK, van Dam L, Visscher M, Polderman PE, Hartlmüller C, de Ruiter H, Hora M, Liesinger L, Birner-Gruenberger R, Vos HR, Reif B, Madl T, Dansen TB
Redox biology 2020 Jan;28:101316
Redox biology 2020 Jan;28:101316
Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.
Dang Y, An Y, He J, Huang B, Zhu J, Gao M, Zhang S, Wang X, Yang B, Xie Z
Aging cell 2020 Jan;19(1):e13060
Aging cell 2020 Jan;19(1):e13060
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1 - CD44 axis.
Godavarthy PS, Kumar R, Herkt SC, Pereira RS, Hayduk N, Weissenberger ES, Aggoune D, Manavski Y, Lucas T, Pan KT, Voutsinas JM, Wu Q, Müller MC, Saussele S, Oellerich T, Oehler VG, Lausen J, Krause DS
Haematologica 2020 Jan;105(1):136-147
Haematologica 2020 Jan;105(1):136-147
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR.
Feng X, Pan J, Li J, Zeng C, Qi W, Shao Y, Liu X, Liu L, Xiao G, Zhang H, Bai X, Cai D
Aging 2020 Jan 16;12(2):1087-1103
Aging 2020 Jan 16;12(2):1087-1103
Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.
Sethi NS, Kikuchi O, Duronio GN, Stachler MD, McFarland JM, Ferrer-Luna R, Zhang Y, Bao C, Bronson R, Patil D, Sanchez-Vega F, Liu JB, Sicinska E, Lazaro JB, Ligon KL, Beroukhim R, Bass AJ
Nature genetics 2020 Feb;52(2):219-230
Nature genetics 2020 Feb;52(2):219-230
Acetyl-11-keto-β-boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular carcinoma cells in vitro and in vivo.
Wang S, Wang H, Sun B, Li D, Wu J, Li J, Tian X, Qin C, Chang H, Liu Y
Fundamental & clinical pharmacology 2020 Feb;34(1):65-76
Fundamental & clinical pharmacology 2020 Feb;34(1):65-76
Role and mechanism of FLNa and UCP2 in the development of cervical cancer.
Wang A, Liu L, Yuan M, Han S, You X, Zhang H, Lei F, Zhang Y
Oncology reports 2020 Dec;44(6):2656-2668
Oncology reports 2020 Dec;44(6):2656-2668
Increased production of functional small extracellular vesicles in senescent endothelial cells.
Riquelme JA, Takov K, Santiago-Fernández C, Rossello X, Lavandero S, Yellon DM, Davidson SM
Journal of cellular and molecular medicine 2020 Apr;24(8):4871-4876
Journal of cellular and molecular medicine 2020 Apr;24(8):4871-4876
A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.
Li Z, Zhu T, Xu Y, Wu C, Chen J, Ren Y, Kong L, Sun S, Guo W, Wang Y, Jing C, Dong J, Zhou J, Zhang L, Shen Q, Zhou X
American journal of cancer research 2019;9(4):699-713
American journal of cancer research 2019;9(4):699-713
Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer.
Guo S, Jian L, Tao K, Chen C, Yu H, Liu S
Frontiers in oncology 2019;9:1325
Frontiers in oncology 2019;9:1325
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.
Li Y, Li X, Cao M, Jiang Y, Yan J, Liu Z, Yang R, Chen X, Sun P, Xiang R, Wang L, Shi Y
Signal transduction and targeted therapy 2019;4:50
Signal transduction and targeted therapy 2019;4:50
NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling.
Liu F, Shi J, Zhang Y, Lian A, Han X, Zuo K, Liu M, Zheng T, Zou F, Liu X, Jin M, Mu Y, Li G, Su G, Liu J
Oxidative medicine and cellular longevity 2019;2019:4286213
Oxidative medicine and cellular longevity 2019;2019:4286213
New Insights into Chronological Mobility of Retrotransposons In Vivo.
Ghanam AR, Cao J, Ouyang X, Song X
Oxidative medicine and cellular longevity 2019;2019:2818415
Oxidative medicine and cellular longevity 2019;2019:2818415
Overexpression of P16 reversed the MDR1-mediated DDP resistance in the cervical adenocarcinoma by activating the ERK1/2 signaling pathway.
Xiao Y, Liang MR, Liu CC, Wang YN, Zeng Y, Zhou J, Zhu HT, Wang Q, Zou Y, Zeng SY
Cell division 2019;14:6
Cell division 2019;14:6
Interferon Regulatory Factor 3 Deficiency Induces Age-Related Alterations of the Retina in Young and Old Mice.
Zhang X, Zhu J, Chen X, Jie-Qiong Z, Li X, Luo L, Huang H, Liu W, Zhou X, Yan J, Lin S, Ye J
Frontiers in cellular neuroscience 2019;13:272
Frontiers in cellular neuroscience 2019;13:272
P16 Methylation Leads to Paclitaxel Resistance of Advanced Non-Small Cell Lung Cancer.
Liu Z, Lin H, Gan Y, Cui C, Zhang B, Gu L, Zhou J, Zhu G, Deng D
Journal of Cancer 2019;10(7):1726-1733
Journal of Cancer 2019;10(7):1726-1733
Inhibition of polycomb repressor complex 2 ameliorates neointimal hyperplasia by suppressing trimethylation of H3K27 in vascular smooth muscle cells.
Liang J, Li Q, Cai W, Zhang X, Yang B, Li X, Jiang S, Tian S, Zhang K, Song H, Ai D, Zhang X, Wang C, Zhu Y
British journal of pharmacology 2019 Sep;176(17):3206-3219
British journal of pharmacology 2019 Sep;176(17):3206-3219
Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence.
Saxena S, Vekaria H, Sullivan PG, Seifert AW
Nature communications 2019 Sep 27;10(1):4400
Nature communications 2019 Sep 27;10(1):4400
Tumor necrosis factor-inducible gene 6 reprograms hepatic stellate cells into stem-like cells, which ameliorates liver damage in mouse.
Wang S, Kim J, Lee C, Oh D, Han J, Kim TJ, Kim SW, Seo YS, Oh SH, Jung Y
Biomaterials 2019 Oct;219:119375
Biomaterials 2019 Oct;219:119375
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
Tian S, Feng J, Cao Y, Shen S, Cai Y, Yang D, Yan R, Wang L, Zhang H, Zhong X, Gao P
Life science alliance 2019 Oct;2(5)
Life science alliance 2019 Oct;2(5)
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
Yang J, Zeng Z, Qiao L, Jiang X, Ma J, Wang J, Ye S, Ma Q, Wei J, Wu M, Huang X, Ma D, Gao Q
Molecular cancer research : MCR 2019 Oct;17(10):2015-2028
Molecular cancer research : MCR 2019 Oct;17(10):2015-2028
Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.
Malaise O, Tachikart Y, Constantinides M, Mumme M, Ferreira-Lopez R, Noack S, Krettek C, Noël D, Wang J, Jorgensen C, Brondello JM
Aging 2019 Oct 22;11(20):9128-9146
Aging 2019 Oct 22;11(20):9128-9146
Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging.
Guo Y, Li H, Ke X, Deng M, Wu Z, Cai Y, Afewerky HK, Zhang X, Pei L, Lu Y
Molecular neurobiology 2019 May;56(5):3368-3379
Molecular neurobiology 2019 May;56(5):3368-3379
The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.
Cho W, Jin X, Pang J, Wang Y, Mivechi NF, Moskophidis D
Molecular and cellular biology 2019 May 1;39(9)
Molecular and cellular biology 2019 May 1;39(9)
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence.
Li R, Liu Y, Xie J, Huang X, Zhang L, Liu H, Li L
Free radical biology & medicine 2019 May 1;135:116-124
Free radical biology & medicine 2019 May 1;135:116-124
Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways.
Liang X, Ding Y, Lin F, Zhang Y, Zhou X, Meng Q, Lu X, Jiang G, Zhu H, Chen Y, Lian Q, Fan H, Liu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Mar;33(3):4559-4570
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Mar;33(3):4559-4570
Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways.
Wei X, Luo D, Yan Y, Yu H, Sun L, Wang C, Song F, Ge H, Qian H, Li X, Tang X, Liu P
Experimental eye research 2019 Mar;180:174-183
Experimental eye research 2019 Mar;180:174-183
Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability.
Shen Z, Liao X, Shao Z, Feng M, Yuan J, Wang S, Gan S, Ha Y, He Z, Jie W
BMC cancer 2019 Mar 22;19(1):262
BMC cancer 2019 Mar 22;19(1):262
Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis.
Saito N, Araya J, Ito S, Tsubouchi K, Minagawa S, Hara H, Ito A, Nakano T, Hosaka Y, Ichikawa A, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kurita Y, Kobayashi K, Hashimoto M, Wakui H, Numata T, Kaneko Y, Asano H, Odaka M, Ohtsuka T, Morikawa T, Nakayama K, Kuwano K
Journal of immunology (Baltimore, Md. : 1950) 2019 Mar 1;202(5):1428-1440
Journal of immunology (Baltimore, Md. : 1950) 2019 Mar 1;202(5):1428-1440
MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1.
Cao Z, Xue J, Cheng Y, Wang J, Liu Y, Li H, Jiang W, Li G, Gui Y, Zhang X
Oncogene 2019 Jun;38(24):4835-4855
Oncogene 2019 Jun;38(24):4835-4855
Fra-1 plays a critical role in angiotensin II-induced vascular senescence.
Yang D, Xiao C, Long F, Wu W, Huang M, Qu L, Liu X, Zhu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7603-7614
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7603-7614
The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway.
Xu S, Wu W, Huang H, Huang R, Xie L, Su A, Liu S, Zheng R, Yuan Y, Zheng HL, Sun X, Xiong XD, Liu X
Aging cell 2019 Jun;18(3):e12918
Aging cell 2019 Jun;18(3):e12918
Correlation of p16 and nm23-H1 expression levels with incidence and prognosis of soft tissue sarcoma.
Jia J, Yin P, Zhang X, Yang F, Song G, Bi W, Han G, Xu M, Wang W, Zheng X
Oncology letters 2019 Jun;17(6):4865-4870
Oncology letters 2019 Jun;17(6):4865-4870
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells.
Delfarah A, Parrish S, Junge JA, Yang J, Seo F, Li S, Mac J, Wang P, Fraser SE, Graham NA
The Journal of biological chemistry 2019 Jul 5;294(27):10564-10578
The Journal of biological chemistry 2019 Jul 5;294(27):10564-10578
Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer.
Li Y, Kong R, Chen H, Zhao Z, Li L, Li J, Hu J, Zhang G, Pan S, Wang Y, Wang G, Chen H, Sun B
Aging 2019 Jul 21;11(14):5035-5057
Aging 2019 Jul 21;11(14):5035-5057
Cathepsin S Deficiency Mitigated Chronic Stress-Related Neointimal Hyperplasia in Mice.
Wang H, Meng X, Piao L, Inoue A, Xu W, Yu C, Nakamura K, Hu L, Sasaki T, Wu H, Unno K, Umegaki H, Murohara T, Shi GP, Kuzuya M, Cheng XW
Journal of the American Heart Association 2019 Jul 16;8(14):e011994
Journal of the American Heart Association 2019 Jul 16;8(14):e011994
Aberrant methylation-induced dysfunction of p16 is associated with osteoblast activation caused by fluoride.
Wu S, Yan W, Qiu B, Liao Y, Gu J, Wei S, Zhang A, Pan X
Environmental toxicology 2019 Jan;34(1):37-47
Environmental toxicology 2019 Jan;34(1):37-47
S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α.
Su Y, Xu C, Sun Z, Liang Y, Li G, Tong T, Chen J
Aging 2019 Jan 23;11(2):549-572
Aging 2019 Jan 23;11(2):549-572
lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs.
Lin X, Zhan JK, Zhong JY, Wang YJ, Wang Y, Li S, He JY, Tan P, Chen YY, Liu XB, Cui XJ, Liu YS
Aging 2019 Jan 17;11(2):523-535
Aging 2019 Jan 17;11(2):523-535
Phenotypic and functional differences between senescent and aged murine microglia.
Stojiljkovic MR, Ain Q, Bondeva T, Heller R, Schmeer C, Witte OW
Neurobiology of aging 2019 Feb;74:56-69
Neurobiology of aging 2019 Feb;74:56-69
Shuttling SLC2A4RG is regulated by 14-3-3θ to modulate cell survival via caspase-3 and caspase-6 in human glioma.
Yun D, Wang H, Wang Y, Chen Y, Zhao Z, Ma J, Ji Y, Huang Q, Chen J, Chen H, Lu D
EBioMedicine 2019 Feb;40:163-175
EBioMedicine 2019 Feb;40:163-175
p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation.
Yoon MH, Kang SM, Lee SJ, Woo TG, Oh AY, Park S, Ha NC, Park BJ
Cell death & disease 2019 Feb 6;10(2):107
Cell death & disease 2019 Feb 6;10(2):107
A basal-enriched microRNA is required for prostate tumorigenesis in a Pten knockout mouse model.
Fan X, Bjerke GA, Riemondy K, Wang L, Yi R
Molecular carcinogenesis 2019 Dec;58(12):2241-2253
Molecular carcinogenesis 2019 Dec;58(12):2241-2253
Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway.
Li T, Xiong Y, Wang Q, Chen F, Zeng Y, Yu X, Wang Y, Zhou F, Zhou Y
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):4001-4011
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):4001-4011
Roles of p38α and p38β mitogen‑activated protein kinase isoforms in human malignant melanoma A375 cells.
Wen SY, Cheng SY, Ng SC, Aneja R, Chen CJ, Huang CY, Kuo WW
International journal of molecular medicine 2019 Dec;44(6):2123-2132
International journal of molecular medicine 2019 Dec;44(6):2123-2132
Releasing Behavior of Lipopolysaccharide from Gelatin Modulates Inflammation, Cellular Senescence, and Bone Formation in Critical-Sized Bone Defects in Rat Calvaria.
Zhao J, Honda Y, Tanaka T, Hashimoto Y, Matsumoto N
Materials (Basel, Switzerland) 2019 Dec 23;13(1)
Materials (Basel, Switzerland) 2019 Dec 23;13(1)
Dipeptidyl peptidase-4 inhibition prevents vascular aging in mice under chronic stress: Modulation of oxidative stress and inflammation.
Xin M, Jin X, Cui X, Jin C, Piao L, Wan Y, Xu S, Zhang S, Yue X, Wang H, Nan Y, Cheng X
Chemico-biological interactions 2019 Dec 1;314:108842
Chemico-biological interactions 2019 Dec 1;314:108842
Senescence caused by inactivation of the homeodomain transcription factor Pdx1 in adult pancreatic acinar cells in mice.
Horiguchi M, Yoshida M, Hirata K, Furuyama K, Masui T, Uemoto S, Kawaguchi Y
FEBS letters 2019 Aug;593(16):2226-2234
FEBS letters 2019 Aug;593(16):2226-2234
Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells.
Sui A, Xu Y, Pan B, Guo T, Wu J, Shen Y, Yang J, Guo X
Journal of cellular physiology 2019 Aug;234(10):17990-17998
Journal of cellular physiology 2019 Aug;234(10):17990-17998
MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages.
An J, Naruse TK, Hinohara K, Soejima Y, Sawabe M, Nakagawa Y, Kuwahara K, Kimura A
Journal of molecular and cellular cardiology 2019 Aug;133:26-35
Journal of molecular and cellular cardiology 2019 Aug;133:26-35
PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.
Jiang Y, Liu F, Zou F, Zhang Y, Wang B, Zhang Y, Lian A, Han X, Liu Z, Liu X, Jin M, Wang D, Li G, Liu J
Stem cell research & therapy 2019 Aug 23;10(1):268
Stem cell research & therapy 2019 Aug 23;10(1):268
Stem cell competition orchestrates skin homeostasis and ageing.
Liu N, Matsumura H, Kato T, Ichinose S, Takada A, Namiki T, Asakawa K, Morinaga H, Mohri Y, De Arcangelis A, Geroges-Labouesse E, Nanba D, Nishimura EK
Nature 2019 Apr;568(7752):344-350
Nature 2019 Apr;568(7752):344-350
Histone Deacetylation in the Promoter of p16 Is Involved in Fluoride-Induced Human Osteoblast Activation via the Inhibition of Sp1 Binding.
Ming J, Wu S, You T, Wang X, Yu C, Luo P, Zhang A, Pan X
Biological trace element research 2019 Apr;188(2):373-383
Biological trace element research 2019 Apr;188(2):373-383
Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo.
Xiong Y, Li T, Assani G, Ling H, Zhou Q, Zeng Y, Zhou F, Zhou Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108602
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108602
A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal.
Tu Q, Yang D, Zhang X, Jia X, An S, Yan L, Dai H, Ma Y, Tang C, Tong W, Hou Z, Lv L, Tan J, Zhao X
Disease models & mechanisms 2019 Apr 15;12(4)
Disease models & mechanisms 2019 Apr 15;12(4)
Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production.
Wang Z, Wang Y, Wang S, Meng X, Song F, Huo W, Zhang S, Chang J, Li J, Zheng B, Liu Y, Zhang Y, Zhang W, Yu J
Frontiers in cellular and infection microbiology 2018;8:279
Frontiers in cellular and infection microbiology 2018;8:279
NRF2-regulated cell cycle arrest at early stage of oxidative stress response mechanism.
Márton M, Tihanyi N, Gyulavári P, Bánhegyi G, Kapuy O
PloS one 2018;13(11):e0207949
PloS one 2018;13(11):e0207949
Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence.
Li Y, Peng Z, Wang C, Li L, Leng Y, Chen R, Yuan H, Zhou S, Zhang Z, Chen AF
American journal of physiology. Heart and circulatory physiology 2018 Sep 1;315(3):H571-H580
American journal of physiology. Heart and circulatory physiology 2018 Sep 1;315(3):H571-H580
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Xing SS, Li J, Chen L, Yang YF, He PL, Li J, Yang J
Mechanisms of ageing and development 2018 Oct;175:1-6
Mechanisms of ageing and development 2018 Oct;175:1-6
Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma.
Mohamed AD, Shah N, Hettmer S, Vargesson N, Wackerhage H
Scientific reports 2018 Oct 23;8(1):15674
Scientific reports 2018 Oct 23;8(1):15674
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, Ying M
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Comparative characterization of SHED and DPSCs during extended cultivation in vitro.
Wang H, Zhong Q, Yang T, Qi Y, Fu M, Yang X, Qiao L, Ling Q, Liu S, Zhao Y
Molecular medicine reports 2018 May;17(5):6551-6559
Molecular medicine reports 2018 May;17(5):6551-6559
Counteracting survival functions of EBNA3C in Epstein-Barr virus (EBV)-driven lymphoproliferative diseases by combination of SAHA and bortezomib.
Hui KF, Yeung PL, Tam KP, Chiang AKS
Oncotarget 2018 May 18;9(38):25101-25114
Oncotarget 2018 May 18;9(38):25101-25114
Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.
Beaver LM, Lӧhr CV, Clarke JD, Glasser ST, Watson GW, Wong CP, Zhang Z, Williams DE, Dashwood RH, Shannon J, Thuillier P, Ho E
Current developments in nutrition 2018 Mar;2(3):nzy002
Current developments in nutrition 2018 Mar;2(3):nzy002
Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis.
Yang F, Yi M, Liu Y, Wang Q, Hu Y, Deng H
Journal of proteome research 2018 Mar 2;17(3):1091-1100
Journal of proteome research 2018 Mar 2;17(3):1091-1100
Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer.
Thangavel C, Boopathi E, Liu Y, McNair C, Haber A, Perepelyuk M, Bhardwaj A, Addya S, Ertel A, Shoyele S, Birbe R, Salvino JM, Dicker AP, Knudsen KE, Den RB
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Mar 15;24(6):1402-1414
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Mar 15;24(6):1402-1414
Identification of early indicators of altered metabolism in normal development using a rodent model system.
Prabakaran AD, Karakkat JV, Vijayan R, Chalissery J, Ibrahim MF, Kaimala S, Adeghate EA, Al-Marzouqi AH, Ansari SA, Mensah-Brown E, Emerald BS
Disease models & mechanisms 2018 Mar 1;11(3)
Disease models & mechanisms 2018 Mar 1;11(3)
Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice.
Roselló-Díez A, Madisen L, Bastide S, Zeng H, Joyner AL
PLoS biology 2018 Jun;16(6):e2005086
PLoS biology 2018 Jun;16(6):e2005086
Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells.
Sun Y, Zheng Y, Wang C, Liu Y
Cell death & disease 2018 Jul 9;9(7):753
Cell death & disease 2018 Jul 9;9(7):753
Overexpression of PP1-NIPP1 limits the capacity of cells to repair DNA double-strand breaks.
Winkler C, Rouget R, Wu D, Beullens M, Van Eynde A, Bollen M
Journal of cell science 2018 Jul 9;131(13)
Journal of cell science 2018 Jul 9;131(13)
Atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats through a mechanism involving down-regulation of miR-21-5p/203a-3p.
Zhang JJ, Zhang YZ, Peng JJ, Li NS, Xiong XM, Ma QL, Luo XJ, Liu B, Peng J
Mechanisms of ageing and development 2018 Jan;169:10-18
Mechanisms of ageing and development 2018 Jan;169:10-18
Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma.
Hamada S, Shimosegawa T, Taguchi K, Nabeshima T, Yamamoto M, Masamune A
American journal of physiology. Gastrointestinal and liver physiology 2018 Jan 1;314(1):G65-G74
American journal of physiology. Gastrointestinal and liver physiology 2018 Jan 1;314(1):G65-G74
EZH2 inhibition sensitizes tamoxifen‑resistant breast cancer cells through cell cycle regulation.
Chen S, Yao F, Xiao Q, Liu Q, Yang Y, Li X, Jiang G, Kuno T, Fang Y
Molecular medicine reports 2018 Feb;17(2):2642-2650
Molecular medicine reports 2018 Feb;17(2):2642-2650
Young plasma reverses age-dependent alterations in hepatic function through the restoration of autophagy.
Liu A, Guo E, Yang J, Yang Y, Liu S, Jiang X, Hu Q, Dirsch O, Dahmen U, Zhang C, Gewirtz DA, Fang H
Aging cell 2018 Feb;17(1)
Aging cell 2018 Feb;17(1)
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
Chen YA, Tzeng DTW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH, Lai CH
Cancers 2018 Dec 31;11(1)
Cancers 2018 Dec 31;11(1)
LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1.
Liu Y, Wang LL, Chen S, Zong ZH, Guan X, Zhao Y
Journal of cellular and molecular medicine 2018 Aug;22(8):3955-3964
Journal of cellular and molecular medicine 2018 Aug;22(8):3955-3964
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.
Masaldan S, Clatworthy SAS, Gamell C, Meggyesy PM, Rigopoulos AT, Haupt S, Haupt Y, Denoyer D, Adlard PA, Bush AI, Cater MA
Redox biology 2018 Apr;14:100-115
Redox biology 2018 Apr;14:100-115
H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing.
Wu W, Hou CL, Mu XP, Sun C, Zhu YC, Wang MJ, Lv QZ
Oxidative medicine and cellular longevity 2017;2017:5707830
Oxidative medicine and cellular longevity 2017;2017:5707830
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation
Tamgue O, Lei M
Asian Pacific journal of cancer prevention : APJCP 2017 Sep 27;18(9):2519-2526
Asian Pacific journal of cancer prevention : APJCP 2017 Sep 27;18(9):2519-2526
Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress.
Lei Y, Yang G, Hu L, Piao L, Inoue A, Jiang H, Sasaki T, Zhao G, Yisireyili M, Yu C, Xu W, Takeshita K, Okumura K, Kuzuya M, Cheng XW, FAHA.
International journal of cardiology 2017 Sep 15;243:413-420
International journal of cardiology 2017 Sep 15;243:413-420
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.
Suzuki Y, Sato T, Sugimoto M, Baskoro H, Karasutani K, Mitsui A, Nurwidya F, Arano N, Kodama Y, Hirano SI, Ishigami A, Seyama K, Takahashi K
Biochemical and biophysical research communications 2017 Oct 7;492(1):74-81
Biochemical and biophysical research communications 2017 Oct 7;492(1):74-81
5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1.
Altieri P, Murialdo R, Barisione C, Lazzarini E, Garibaldi S, Fabbi P, Ruggeri C, Borile S, Carbone F, Armirotti A, Canepa M, Ballestrero A, Brunelli C, Montecucco F, Ameri P, Spallarossa P
British journal of pharmacology 2017 Nov;174(21):3713-3726
British journal of pharmacology 2017 Nov;174(21):3713-3726
Potency of Human Cardiosphere-Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability.
Harvey E, Zhang H, Sepúlveda P, Garcia SP, Sweeney D, Choudry FA, Castellano D, Thomas GN, Kattach H, Petersen R, Blake DJ, Taggart DP, Frontini M, Watt SM, Martin-Rendon E
Stem cells translational medicine 2017 May;6(5):1399-1411
Stem cells translational medicine 2017 May;6(5):1399-1411
A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis.
Wang S, Cao Z, Xue J, Li H, Jiang W, Cheng Y, Li G, Zhang X
The Journal of biological chemistry 2017 May 19;292(20):8207-8222
The Journal of biological chemistry 2017 May 19;292(20):8207-8222
Activation of Wnt/β-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging.
Xia MY, Zhao XY, Huang QL, Sun HY, Sun C, Yuan J, He C, Sun Y, Huang X, Kong W, Kong WJ
FEBS open bio 2017 Jun;7(6):759-776
FEBS open bio 2017 Jun;7(6):759-776
miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1.
Zhang JJ, Liu WQ, Peng JJ, Ma QL, Peng J, Luo XJ
Mechanisms of ageing and development 2017 Jun;164:8-19
Mechanisms of ageing and development 2017 Jun;164:8-19
Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8.
Peng C, Hu W, Weng X, Tong R, Cheng S, Ding C, Xiao H, Lv Z, Xie H, Zhou L, Wu J, Zheng S
Scientific reports 2017 Jun 23;7(1):4186
Scientific reports 2017 Jun 23;7(1):4186
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
Mao X, Li P, Wang Y, Liang Z, Liu J, Li J, Jiang Y, Bao G, Li L, Zhu B, Ren Y, Zhao X, Zhang J, Liu Y, Yang J, Liu P
Cell death & disease 2017 Jan 12;8(1):e2546
Cell death & disease 2017 Jan 12;8(1):e2546
Knockout of 4.1B triggers malignant transformation in SV40T-immortalized mouse embryo fibroblast cells.
Wang Z, Zhang J, Zeng Y, Sun S, Zhang J, Zhang B, Zhu M, Ouyang R, Ma B, Ye M, An X, Liu J
Molecular carcinogenesis 2017 Feb;56(2):538-549
Molecular carcinogenesis 2017 Feb;56(2):538-549
MicroRNA let-7g inhibited hypoxia-induced proliferation of PASMCs via G0/G1 cell cycle arrest by targeting c-myc.
Zhang WF, Xiong YW, Zhu TT, Xiong AZ, Bao HH, Cheng XS
Life sciences 2017 Feb 1;170:9-15
Life sciences 2017 Feb 1;170:9-15
Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent.
Frescas D, Hall BM, Strom E, Virtuoso LP, Gupta M, Gleiberman AS, Rydkina E, Balan V, Vujcic S, Chernova OB, Gudkov AV
Cell cycle (Georgetown, Tex.) 2017 Aug 18;16(16):1526-1533
Cell cycle (Georgetown, Tex.) 2017 Aug 18;16(16):1526-1533
Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.
Watanabe R, Fujita N, Sato Y, Kobayashi T, Morita M, Oike T, Miyamoto K, Kuro-O M, Michigami T, Fukumoto S, Tsuji T, Toyama Y, Nakamura M, Matsumoto M, Miyamoto T
Scientific reports 2017 Aug 10;7(1):7786
Scientific reports 2017 Aug 10;7(1):7786
Long-term effects of repeated superovulation on the uterus and mammary gland in rhesus monkeys.
Yan P, Xu J, Zeng Y, Dong G, Cao H, Zheng M, Zhu H
Journal of assisted reproduction and genetics 2017 Apr;34(4):535-545
Journal of assisted reproduction and genetics 2017 Apr;34(4):535-545
N-Stearoyl-L-Tyrosine Inhibits the Senescence of Neural Stem/Progenitor Cells Induced by Aβ 1-42 via the CB2 Receptor.
Li WQ, Wang ZJ, Liu S, Hu Y, Yin M, Lu Y
Stem cells international 2016;2016:7419389
Stem cells international 2016;2016:7419389
Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D-Galactose.
Chen H, Long Y, Guo L
Evidence-based complementary and alternative medicine : eCAM 2016;2016:6049083
Evidence-based complementary and alternative medicine : eCAM 2016;2016:6049083
Inhibition of BMI1 induces autophagy-mediated necroptosis.
Dey A, Mustafi SB, Saha S, Kumar Dhar Dwivedi S, Mukherjee P, Bhattacharya R
Autophagy 2016;12(4):659-70
Autophagy 2016;12(4):659-70
Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response.
Nomanbhoy TK, Sharma G, Brown H, Wu J, Aban A, Vogeti S, Alemayehu S, Sykes M, Rosenblum JS, Kozarich JW
Biochemistry 2016 Sep 27;55(38):5434-41
Biochemistry 2016 Sep 27;55(38):5434-41
Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation.
Xu X, Pang J, Chen Y, Bucala R, Zhang Y, Ren J
Scientific reports 2016 Mar 4;6:22488
Scientific reports 2016 Mar 4;6:22488
miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.
Feng T, Shao F, Wu Q, Zhang X, Xu D, Qian K, Xie Y, Wang S, Xu N, Wang Y, Qi C
Oncotarget 2016 Mar 29;7(13):16205-16
Oncotarget 2016 Mar 29;7(13):16205-16
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.
Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, Hu N, Xue J, Li H, Jiang W, Li G, Zhang X
The Journal of biological chemistry 2016 Jun 10;291(24):12688-12705
The Journal of biological chemistry 2016 Jun 10;291(24):12688-12705
The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity.
Lazzarini E, Balbi C, Altieri P, Pfeffer U, Gambini E, Canepa M, Varesio L, Bosco MC, Coviello D, Pompilio G, Brunelli C, Cancedda R, Ameri P, Bollini S
Scientific reports 2016 Jul 21;6:29994
Scientific reports 2016 Jul 21;6:29994
Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes.
Altieri P, Barisione C, Lazzarini E, Garuti A, Bezante GP, Canepa M, Spallarossa P, Tocchetti CG, Bollini S, Brunelli C, Ameri P
Journal of the American Heart Association 2016 Jan 8;5(1)
Journal of the American Heart Association 2016 Jan 8;5(1)
Comparison of liver oncogenic potential among human RAS isoforms.
Chung SI, Moon H, Ju HL, Kim DY, Cho KJ, Ribback S, Dombrowski F, Calvisi DF, Ro SW
Oncotarget 2016 Feb 9;7(6):7354-66
Oncotarget 2016 Feb 9;7(6):7354-66
Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis.
Vermeer DW, Coppock JD, Zeng E, Lee KM, Spanos WC, Onken MD, Uppaluri R, Lee JH, Vermeer PD
Oncotarget 2016 Apr 26;7(17):24194-207
Oncotarget 2016 Apr 26;7(17):24194-207
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.
Rajendran P, Dashwood WM, Li L, Kang Y, Kim E, Johnson G, Fischer KA, Löhr CV, Williams DE, Ho E, Yamamoto M, Lieberman DA, Dashwood RH
Clinical epigenetics 2015;7:102
Clinical epigenetics 2015;7:102
Lentivirus-mediated gene silencing of NOB1 suppresses non-small cell lung cancer cell proliferation.
Huang W, Zhong W, Xu J, Su B, Huang G, Du J, Liu Q
Oncology reports 2015 Sep;34(3):1510-6
Oncology reports 2015 Sep;34(3):1510-6
Evaluation of Protein Profiles From Treated Xenograft Tumor Models Identifies an Antibody Panel for Formalin-fixed and Paraffin-embedded (FFPE) Tissue Analysis by Reverse Phase Protein Arrays (RPPA).
Bader S, Zajac M, Friess T, Ruge E, Rieder N, Gierke B, Heubach Y, Thomas M, Pawlak M
Molecular & cellular proteomics : MCP 2015 Oct;14(10):2775-85
Molecular & cellular proteomics : MCP 2015 Oct;14(10):2775-85
Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction.
Al-Wahab Z, Mert I, Tebbe C, Chhina J, Hijaz M, Morris RT, Ali-Fehmi R, Giri S, Munkarah AR, Rattan R
Oncotarget 2015 May 10;6(13):10908-23
Oncotarget 2015 May 10;6(13):10908-23
Cathepsin K knockout alleviates aging-induced cardiac dysfunction.
Hua Y, Robinson TJ, Cao Y, Shi GP, Ren J, Nair S
Aging cell 2015 Jun;14(3):345-51
Aging cell 2015 Jun;14(3):345-51
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M
Cancer cell 2015 Jan 12;27(1):41-56
Cancer cell 2015 Jan 12;27(1):41-56
Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies.
Jäger W, Xue H, Hayashi T, Janssen C, Awrey S, Wyatt AW, Anderson S, Moskalev I, Haegert A, Alshalalfa M, Erho N, Davicioni E, Fazli L, Li E, Collins C, Wang Y, Black PC
Oncotarget 2015 Aug 28;6(25):21522-32
Oncotarget 2015 Aug 28;6(25):21522-32
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Fullerenol protects retinal pigment epithelial cells from oxidative stress-induced premature senescence via activating SIRT1.
Zhuge CC, Xu JY, Zhang J, Li W, Li P, Li Z, Chen L, Liu X, Shang P, Xu H, Lu Y, Wang F, Lu L, Xu GT
Investigative ophthalmology & visual science 2014 May 20;55(7):4628-38
Investigative ophthalmology & visual science 2014 May 20;55(7):4628-38
BCL6 overexpression is associated with decreased p19 ARF expression and confers an independent prognosticator in gallbladder carcinoma.
Liang PI, Li CF, Chen LT, Sun DP, Chen TJ, Hsing CH, Hsu HP, Lin CY
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Feb;35(2):1417-26
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Feb;35(2):1417-26
Ocular expression and distribution of products of the POAG-associated chromosome 9p21 gene region.
Chidlow G, Wood JP, Sharma S, Dimasi DP, Burdon KP, Casson RJ, Craig JE
PloS one 2013;8(9):e75067
PloS one 2013;8(9):e75067
Teng-Long-Bu-Zhong-Tang, a Chinese herbal formula, enhances anticancer effects of 5--Fluorouracil in CT26 colon carcinoma.
Deng S, Hu B, An HM, Du Q, Xu L, Shen KP, Shi XF, Wei MM, Wu Y
BMC complementary and alternative medicine 2013 Jun 8;13:128
BMC complementary and alternative medicine 2013 Jun 8;13:128
Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells.
Wang F, Xia X, Wang J, Sun Q, Luo J, Cheng B
Biotechnology letters 2013 Jan;35(1):29-37
Biotechnology letters 2013 Jan;35(1):29-37
Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.
Xu X, Hueckstaedt LK, Ren J
Journal of hepatology 2013 Aug;59(2):308-17
Journal of hepatology 2013 Aug;59(2):308-17
Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells.
Motterle A, Pu X, Wood H, Xiao Q, Gor S, Ng FL, Chan K, Cross F, Shohreh B, Poston RN, Tucker AT, Caulfield MJ, Ye S
Human molecular genetics 2012 Sep 15;21(18):4021-9
Human molecular genetics 2012 Sep 15;21(18):4021-9
Correlation of MTS1/p16 and nm23 mRNA expression with survival in patients with peripheral synovial sarcoma.
Golouh R, Stanta G, Bracko M, Bonin S
Journal of surgical oncology 2001 Feb;76(2):83-8
Journal of surgical oncology 2001 Feb;76(2):83-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10883-1-AP(P16 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of SH-SY5Y cells, using CDKN2A antibody 10883-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-P16 (IP:10883-1-AP, 4ug; Detection:10883-1-AP 1:1000) with HEK-293 cells lysate 4500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 10883-1-AP(P16 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 10883-1-AP(P16 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
