675602

CDKN2A antibody from BioLegend
ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf

Antibody data

Product number
675602
Provider
BioLegend
Proper citation
BioLegend Cat#675602, RRID:AB_2565605
Product name
Purified anti-CDKN2A (p16)
Provider product page
BioLegend - 675602
Antibody type
Monoclonal
Antigen
Full length human CDKN2A recombinant protein expressed in E. coli.
Description
Cyclin-dependent kinase inhibitor 2A (CDKN2A) isoform 1, also known as p16-INK4a, is an inhibitor of the cyclin dependent kinases CDK4 and CDK6. CDKN2A acts as a negative regulator of cell cycle progression by preventing phosphorylation of the retinoblastoma protein (pRb) by cyclin-dependent kinases. CDKN2A expression is upregulated during cellular senescence and aging. It functions as a tumor suppressor to induce cell cycle arrest and aging of normal tissues. Germ line point mutations, homozygous deletion, or promoter methylation in the human CDKN2A locus causes uncontrolled cell proliferation, which results in a variety of malignancies such as melanoma, pancreatic adenocarcinoma, gastric cancer, and esophageal cancer.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
15C10C30
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
Provider Type Product Number
- No reagents -