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LearnNB200-111
antibody from Novus Biologicals
Targeting: CDKN2A
ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- NB200-111 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB200-111, RRID:AB_10000489
- Product name
- Rabbit Polyclonal p14ARF/CDKN2A Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Loss of the clock gene PER2 is associated with cancer development and altered expression of important tumor-related genes in oral cancer.
Novel Roles for Staufen1 in Embryonal and Alveolar Rhabdomyosarcoma via c-myc-dependent and -independent events.
Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth.
Curcumin homing to the nucleolus: mechanism for initiation of an apoptotic program.
AKT regulates NPM dependent ARF localization and p53mut stability in tumors.
TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation.
The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis.
Who chooses the leaders of UN organisations?
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses.
Reactivating the ARF-p53 axis in AML cells by targeting ULF.
The role of NPM, p14arf and MDM2 in precursors of bronchial squamous cell carcinoma.
Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis.
Frequent p16-independent inactivation of p14ARF in human melanoma.
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.
N-terminal polyubiquitination and degradation of the Arf tumor suppressor.
The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription.
Xiong H, Yang Y, Yang K, Zhao D, Tang H, Ran X
International journal of oncology 2018 Jan;52(1):279-287
International journal of oncology 2018 Jan;52(1):279-287
Novel Roles for Staufen1 in Embryonal and Alveolar Rhabdomyosarcoma via c-myc-dependent and -independent events.
Crawford Parks TE, Marcellus KA, Langill J, Ravel-Chapuis A, Michaud J, Cowan KN, Côté J, Jasmin BJ
Scientific reports 2017 Feb 17;7:42342
Scientific reports 2017 Feb 17;7:42342
Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth.
Williams RT, Barnhill LM, Kuo HH, Lin WD, Batova A, Yu AL, Diccianni MB
PloS one 2014;9(2):e88219
PloS one 2014;9(2):e88219
Curcumin homing to the nucleolus: mechanism for initiation of an apoptotic program.
Ghosh M, Ryan RO
The Journal of nutritional biochemistry 2014 Nov;25(11):1117-1123
The Journal of nutritional biochemistry 2014 Nov;25(11):1117-1123
AKT regulates NPM dependent ARF localization and p53mut stability in tumors.
Hamilton G, Abraham AG, Morton J, Sampson O, Pefani DE, Khoronenkova S, Grawenda A, Papaspyropoulos A, Jamieson N, McKay C, Sansom O, Dianov GL, O'Neill E
Oncotarget 2014 Aug 15;5(15):6142-67
Oncotarget 2014 Aug 15;5(15):6142-67
TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation.
Chio II, Sasaki M, Ghazarian D, Moreno J, Done S, Ueda T, Inoue S, Chang YL, Chen NJ, Mak TW
Nature cell biology 2012 May 6;14(6):625-33
Nature cell biology 2012 May 6;14(6):625-33
The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis.
Muniz VP, Barnes JM, Paliwal S, Zhang X, Tang X, Chen S, Zamba KD, Cullen JJ, Meyerholz DK, Meyers S, Davis JN, Grossman SR, Henry MD, Quelle DE
Molecular cancer research : MCR 2011 Jul;9(7):867-77
Molecular cancer research : MCR 2011 Jul;9(7):867-77
Who chooses the leaders of UN organisations?
Greiner T
Lancet (London, England) 2010 Mar 27;375(9720):1082
Lancet (London, England) 2010 Mar 27;375(9720):1082
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses.
Chen D, Shan J, Zhu WG, Qin J, Gu W
Nature 2010 Mar 25;464(7288):624-7
Nature 2010 Mar 25;464(7288):624-7
Reactivating the ARF-p53 axis in AML cells by targeting ULF.
Chen D, Yoon JB, Gu W
Cell cycle (Georgetown, Tex.) 2010 Aug 1;9(15):2946-51
Cell cycle (Georgetown, Tex.) 2010 Aug 1;9(15):2946-51
The role of NPM, p14arf and MDM2 in precursors of bronchial squamous cell carcinoma.
Mascaux C, Bex F, Martin B, Burny A, Haller A, Paesmans M, Willard-Gallo K, Ninane V, Sculier JP
The European respiratory journal 2008 Sep;32(3):678-86
The European respiratory journal 2008 Sep;32(3):678-86
Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis.
Wang WH, Hullinger RL, Andrisani OM
The Journal of biological chemistry 2008 Sep 12;283(37):25455-67
The Journal of biological chemistry 2008 Sep 12;283(37):25455-67
Frequent p16-independent inactivation of p14ARF in human melanoma.
Freedberg DE, Rigas SH, Russak J, Gai W, Kaplow M, Osman I, Turner F, Randerson-Moor JA, Houghton A, Busam K, Timothy Bishop D, Bastian BC, Newton-Bishop JA, Polsky D
Journal of the National Cancer Institute 2008 Jun 4;100(11):784-95
Journal of the National Cancer Institute 2008 Jun 4;100(11):784-95
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Miller SJ, Rangwala F, Williams J, Ackerman P, Kong S, Jegga AG, Kaiser S, Aronow BJ, Frahm S, Kluwe L, Mautner V, Upadhyaya M, Muir D, Wallace M, Hagen J, Quelle DE, Watson MA, Perry A, Gutmann DH, Ratner N
Cancer research 2006 Mar 1;66(5):2584-91
Cancer research 2006 Mar 1;66(5):2584-91
p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.
Magro PG, Russo AJ, Li WW, Banerjee D, Bertino JR
Cancer research 2004 Jun 15;64(12):4338-45
Cancer research 2004 Jun 15;64(12):4338-45
N-terminal polyubiquitination and degradation of the Arf tumor suppressor.
Kuo ML, den Besten W, Bertwistle D, Roussel MF, Sherr CJ
Genes & development 2004 Aug 1;18(15):1862-74
Genes & development 2004 Aug 1;18(15):1862-74
The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription.
Fatyol K, Szalay AA
The Journal of biological chemistry 2001 Jul 27;276(30):28421-9
The Journal of biological chemistry 2001 Jul 27;276(30):28421-9
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: p14ARF/CDKN2A Antibody [NB200-111] - Analysis of HeLa Whole Cell Lysate (NB800-PC1) using p14ARF antibody (lot C) employing ECL detection method.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: p14ARF/CDKN2A Antibody [NB200-111] - ARF expression levels in OCI/AML3 cells after proteasome treatment. This image was submitted via customer Review.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Frozen: p14ARF/CDKN2A Antibody [NB200-111] - Mouse brain section, hippocampal (10 um thickness). 3% PFA perfused. 1:1000 dilultion. Image from verified customer review. Image using the Biotin form of this antibody.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: p14ARF/CDKN2A Antibody [NB200-111] - p14ARF antibody was tested at 1:400 in HeLa cells using an Alexa Fluor 488 secondary (shown in purple). M1 is defined by unstained cells.
