RXRG

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Description

Retinoid X receptor gamma

Tissue specificity

Tissue enhanced (brain, pituitary gland, retina, skeletal muscle)

Subcell location

Nucleoplasm, Nuclear bodies

Predicted location

Intracellular

Protein family

Cancer-related genes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors

Chromosome

1 (165400922 - 165445355)

Ensembl ID

ENSG00000143171  (ver. 103.38)

Orthologs

Mouse Rxrg: ENSMUSG00000015843

UniProt

P48443

neXtProt

NX_P48443

Human splice variants
Mouse splice variants

Protein structure