BS3529

antibody from Bioworld Technology, Inc
Targeting: ABI1 ABI-1, E3B1, SSH3BP1
Provider product page for BS3529

Antibody data

Product number
BS3529 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Abi 1 (L201) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 170-220 of Human Abi-1.
Description
The Abl interactor proteins, Abi-1 and Abi-2, are SH3-domain containing proteins that bind to the proline-rich motifs of Abl and activate the kinase function. Two splice variants of Abi-1 are widely expressed, with the highest levels found in bone marrow,spleen, brain and testis. Abi-1 and Abi-2 are thought to negatively regulate cell growth and transformation, including cellular transformation through v-Abl. ABI1, the gene encoding Abi-1, has been shown to translocate and fuse with MLL (mixed lineage leukemia) gene in some cases of acute myeloid leukemia (AML). The Abi proteins have also been identified as mediators of cell motility by regulating Actin polymerization in lamellipodia and filopodia.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ABI1 protein structure - BS3529 shown in red.