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LearnTissue expression
Cell line expression
Protein structure
MME
Membrane metalloendopeptidaseCALLA, CD10, NEP
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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| Proteintech Group |  18008-1-AP |
12 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | MA5-14050 |
58 references | Monoclonal |
WB
IHC
FC
OA
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| R&D Systems | AF1182 |
3 references | Polyclonal |
WB
EL
IP
IHC
FC
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| Novus Biologicals | AF1182 |
3 references | Polyclonal |
WB
IP
IHC
FC
|
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| OriGene | UM800128 |
1 references | Monoclonal |
WB
IHC
FC
OA
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