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Cell line expression
Protein structure
CD59
CD59 molecule (CD59 blood group)16.3A5, EJ16, EJ30, EL32, G344, MIC11, MIN1, MIN2, MIN3, MSK21, p18-20
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| antibodies-online |  ABIN1098134 |
2 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| GeneTex | GTX76425 |
1 references | Monoclonal |
WB
ICC
IHC
FC
BN
FA
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| Proteintech Group | 10742-1-AP |
5 references | Polyclonal |
WB
EL
ICC
IHC
FC
|
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| Invitrogen Antibodies | MA1-19133 |
22 references | Monoclonal |
IP
IHC
FC
OA
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| Novus Biologicals | NB500-330 |
9 references | Monoclonal |
IP
IHC
FC
BN
|
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