BCL3

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]

Description

BCL3 transcription coactivator

Tissue specificity

Tissue enhanced (liver)

Subcell location

Nucleoplasm, Vesicles, Midbody

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

19 (44747705 - 44760044)

Ensembl ID

ENSG00000069399  (ver. 103.38)

Orthologs

Mouse Bcl3: ENSMUSG00000053175

UniProt

P20749

neXtProt

NX_P20749

Human splice variants
Mouse splice variants

Protein structure