Explore
Validate
Learn
Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [121]
- Comments [0]
- Validations
- Western blot [3]
- Immunohistochemistry [7]
Submit
Validation data
Reference
Comment
Report error
- Product number
- NB300-109 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB300-109, RRID:AB_10077691
- Product name
- Rabbit Polyclonal Tyrosine Hydroxylase Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specific for the ~60 kDa tyrosine hydroxylase protein.
- Reactivity
- Human, Mouse, Rat, Drosophila
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 0.15 mg/ml
- Storage
- Store at -20C. Avoid freeze-thaw cycles.
Submitted references Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control.
Loading-induced antitumor capability of murine and human urine.
A selective D2 dopamine receptor agonist alleviates depression through up-regulation of tyrosine hydroxylase and increased neurogenesis in hippocampus of the prenatally stressed rats.
Inhibiting thrombin improves motor function and decreases oxidative stress in the LRRK2 transgenic Drosophila melanogaster model of Parkinson's disease.
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice.
Animal Model for Leigh Syndrome.
Therapeutic Evaluation of Synthetic Peucedanocoumarin III in an Animal Model of Parkinson's Disease.
The autonomic innervation of hairy skin in humans: an in vivo confocal study.
Chemoconnectomics: Mapping Chemical Transmission in Drosophila.
Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration.
Neuroprotective effects of PACAP against paraquat-induced oxidative stress in the Drosophila central nervous system.
Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways.
inPentasomes: An innovative nose-to-brain pentamidine delivery blunts MPTP parkinsonism in mice.
A Neuron-Glial Trans-Signaling Cascade Mediates LRRK2-Induced Neurodegeneration.
The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis.
Palm Fruit Bioactives augment expression of Tyrosine Hydroxylase in the Nile Grass Rat basal ganglia and alter the colonic microbiome.
Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression.
The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Tyrosine hydroxylase-immunoreactive neurons in the mushroom body of the field cricket, Gryllus bimaculatus.
Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells.
Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress.
Characterization of the Sexually Dimorphic fruitless Neurons That Regulate Copulation Duration.
Neural Control of Startle-Induced Locomotion by the Mushroom Bodies and Associated Neurons in Drosophila.
An exercise in brain genoarchitectonics: Analysis of AZIN2-Lacz expressing neuronal populations in the mouse hindbrain.
Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease.
Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65.
Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting.
Behavioral and neurochemical responses derived from dopaminergic intrastriatal grafts in hemiparkinsonian rats engaged in a novel motor task.
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.
Long-term immunosuppression for CNS mouse xenotransplantation: Effects on nigrostriatal neurodegeneration and neuroprotective carotid body cell therapy.
Parkinson's Disease Associated α-Synuclein Familial Mutants Promote Dopaminergic Neuronal Death in Drosophila melanogaster.
A novel extended form of alpha-synuclein 3'UTR in the human brain.
Correction: HIF-2α is essential for carotid body development and function.
PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies.
The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model.
GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers.
PARIS reprograms glucose metabolism by HIF-1α induction in dopaminergic neurodegeneration.
Primary fibroblast co-culture stimulates growth and metabolism in Sdhb-impaired mouse pheochromocytoma MTT cells.
Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model.
D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model.
Cocaine- and Amphetamine-Regulated Transcript Peptide (CART) Alleviates MK-801-Induced Schizophrenic Dementia-Like Symptoms.
Striatal But Not Extrastriatal Dopamine Receptors Are Critical to Dopaminergic Motor Stimulation.
Whole genome expression profiling associates activation of unfolded protein response with impaired production and release of epinephrine after recurrent hypoglycemia.
Gene expression analyses reveal metabolic specifications in acute O(2) -sensing chemoreceptor cells.
Cardiovascular adaptation to hypoxia and the role of peripheral resistance.
Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology.
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection.
Assessment of the acquisition of executive function during the transition from adolescence to adulthood in male and female mice.
Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models.
Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation.
Nociceptive DRG neurons express muscle lim protein upon axonal injury.
Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body.
Dopamine- and Tyrosine Hydroxylase-Immunoreactive Neurons in the Brain of the American Cockroach, Periplaneta americana.
Olfactory Sensory Activity Modulates Microglial-Neuronal Interactions during Dopaminergic Cell Loss in the Olfactory Bulb.
Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines.
LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity.
Involvement of catecholaminergic neurons in motor innervation of striated muscle in the mouse esophagus.
Chronic social isolation enhances reproduction in the monogamous prairie vole (Microtus ochrogaster).
Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease.
Thiazine Red(+) platelet inclusions in Cerebral Blood Vessels are first signs in an Alzheimer's Disease mouse model.
Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice.
Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons.
Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway.
Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone.
HIF2α-arginase axis is essential for the development of pulmonary hypertension.
Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model.
Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.
Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease.
Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.
PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine.
Similar L-dopa-stimulated motor activity in mice with adult-onset 6-hydroxydopamine-induced symmetric dopamine denervation and in transcription factor Pitx3 null mice with perinatal-onset symmetric dopamine denervation.
Mitochondrial complex I defects increase ubiquitin in substantia nigra.
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.
Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue.
An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia.
Age-mediated transcriptomic changes in adult mouse substantia nigra.
Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.
Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia.
Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice.
Innervation pattern of the preocular human central retinal artery.
Neuroprotective and reparative effects of carotid body grafts in a chronic MPTP model of Parkinson's disease.
Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model.
Cellular properties and chemosensory responses of the human carotid body.
Severe nigrostriatal degeneration without clinical parkinsonism in patients with polymerase gamma mutations.
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice: old switch, new target.
Single dopaminergic neurons that modulate aggression in Drosophila.
Parallel dopamine D1 receptor activity dependence of l-Dopa-induced normal movement and dyskinesia in mice.
Adaptive alternative splicing correlates with less environmental risk of parkinsonism.
Development and characterization of a new Parkinson's disease model resulting from impaired autophagy.
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.
GDNF is predominantly expressed in the PV+ neostriatal interneuronal ensemble in normal mouse and after injury of the nigrostriatal pathway.
Differential impairment of catecholaminergic cell maturation and survival by genetic mitochondrial complex II dysfunction.
Expression of the neuregulin receptor ErbB4 in the brain of the rhesus monkey (Macaca mulatta).
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
Brain stem catecholamines circuitry: activation by alcohol and role in the hypothalamic-pituitary-adrenal response to this drug.
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
Targeted manipulation of serotonergic neurotransmission affects the escalation of aggression in adult male Drosophila melanogaster.
Effects of IL-6 secreted from astrocytes on the survival of dopaminergic neurons in lipopolysaccharide-induced inflammation.
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.
Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase.
Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity.
Adaptive acetylcholinesterase splicing patterns attenuate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice.
Loss of locus coeruleus neurons and reduced startle in parkin null mice.
A hypothalamic-testicular neural pathway is influenced by brain catecholamines, but not testicular blood flow.
Central pathways in the pons and midbrain involved in cardiac sympathoexcitatory reflexes in cats.
Central pathways in the pons and midbrain involved in cardiac sympathoexcitatory reflexes in cats.
Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group.
Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group.
Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat.
Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat.
Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia.
Cheng X, Prange-Barczynska M, Fielding JW, Zhang M, Burrell AL, Lima JD, Eckardt L, Argles I, Pugh CW, Buckler KJ, Robbins PA, Hodson EJ, Bruick RK, Collinson LM, Rastinejad F, Bishop T, Ratcliffe PJ
The Journal of clinical investigation 2020 May 1;130(5):2237-2251
The Journal of clinical investigation 2020 May 1;130(5):2237-2251
Loading-induced antitumor capability of murine and human urine.
Wu D, Fan Y, Liu S, Woollam MD, Sun X, Murao E, Zha R, Prakash R, Park C, Siegel AP, Liu J, Agarwal M, Li BY, Yokota H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):7578-7592
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):7578-7592
A selective D2 dopamine receptor agonist alleviates depression through up-regulation of tyrosine hydroxylase and increased neurogenesis in hippocampus of the prenatally stressed rats.
Fatima M, Ahmad MH, Srivastav S, Rizvi MA, Mondal AC
Neurochemistry international 2020 Jun;136:104730
Neurochemistry international 2020 Jun;136:104730
Inhibiting thrombin improves motor function and decreases oxidative stress in the LRRK2 transgenic Drosophila melanogaster model of Parkinson's disease.
Johnson SL, Iannucci J, Seeram NP, Grammas P
Biochemical and biophysical research communications 2020 Jun 25;527(2):532-538
Biochemical and biophysical research communications 2020 Jun 25;527(2):532-538
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
Thayer JA, Awad O, Hegdekar N, Sarkar C, Tesfay H, Burt C, Zeng X, Feldman RA, Lipinski MM
Autophagy 2020 Jan;16(1):140-153
Autophagy 2020 Jan;16(1):140-153
Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
Moreno-Domínguez A, Ortega-Sáenz P, Gao L, Colinas O, García-Flores P, Bonilla-Henao V, Aragonés J, Hüttemann M, Grossman LI, Weissmann N, Sommer N, López-Barneo J
Science signaling 2020 Jan 21;13(615)
Science signaling 2020 Jan 21;13(615)
Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
Cheng W, Gonzalez I, Pan W, Tsang AH, Adams J, Ndoka E, Gordian D, Khoury B, Roelofs K, Evers SS, MacKinnon A, Wu S, Frikke-Schmidt H, Flak JN, Trevaskis JL, Rhodes CJ, Fukada SI, Seeley RJ, Sandoval DA, Olson DP, Blouet C, Myers MG Jr
Cell metabolism 2020 Feb 4;31(2):301-312.e5
Cell metabolism 2020 Feb 4;31(2):301-312.e5
Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice.
Cheng W, Ndoka E, Hutch C, Roelofs K, MacKinnon A, Khoury B, Magrisso J, Kim KS, Rhodes CJ, Olson DP, Seeley RJ, Sandoval D, Myers MG Jr
JCI insight 2020 Apr 9;5(7)
JCI insight 2020 Apr 9;5(7)
Animal Model for Leigh Syndrome.
El-Desouky S, Taalab YM, El-Gamal M, Mohamed W, Salama M
Methods in molecular biology (Clifton, N.J.) 2019;2011:451-464
Methods in molecular biology (Clifton, N.J.) 2019;2011:451-464
Therapeutic Evaluation of Synthetic Peucedanocoumarin III in an Animal Model of Parkinson's Disease.
Ham S, Kim H, Yoon JH, Kim H, Song BR, Choi JY, Lee YS, Paek SM, Maeng HJ, Lee Y
International journal of molecular sciences 2019 Nov 4;20(21)
International journal of molecular sciences 2019 Nov 4;20(21)
The autonomic innervation of hairy skin in humans: an in vivo confocal study.
Donadio V, Incensi A, Vacchiano V, Infante R, Magnani M, Liguori R
Scientific reports 2019 Nov 18;9(1):16982
Scientific reports 2019 Nov 18;9(1):16982
Chemoconnectomics: Mapping Chemical Transmission in Drosophila.
Deng B, Li Q, Liu X, Cao Y, Li B, Qian Y, Xu R, Mao R, Zhou E, Zhang W, Huang J, Rao Y
Neuron 2019 Mar 6;101(5):876-893.e4
Neuron 2019 Mar 6;101(5):876-893.e4
Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration.
Chen X, Kordich JK, Williams ET, Levine N, Cole-Strauss A, Marshall L, Labrie V, Ma J, Lipton JW, Moore DJ
Proceedings of the National Academy of Sciences of the United States of America 2019 Mar 19;116(12):5765-5774
Proceedings of the National Academy of Sciences of the United States of America 2019 Mar 19;116(12):5765-5774
Neuroprotective effects of PACAP against paraquat-induced oxidative stress in the Drosophila central nervous system.
Hajji K, Mteyrek A, Sun J, Cassar M, Mezghani S, Leprince J, Vaudry D, Masmoudi-Kouki O, Birman S
Human molecular genetics 2019 Jun 1;28(11):1905-1918
Human molecular genetics 2019 Jun 1;28(11):1905-1918
Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways.
Alekseyenko OV, Chan YB, Okaty BW, Chang Y, Dymecki SM, Kravitz EA
Current biology : CB 2019 Jul 8;29(13):2145-2156.e5
Current biology : CB 2019 Jul 8;29(13):2145-2156.e5
inPentasomes: An innovative nose-to-brain pentamidine delivery blunts MPTP parkinsonism in mice.
Rinaldi F, Seguella L, Gigli S, Hanieh PN, Del Favero E, Cantù L, Pesce M, Sarnelli G, Marianecci C, Esposito G, Carafa M
Journal of controlled release : official journal of the Controlled Release Society 2019 Jan 28;294:17-26
Journal of controlled release : official journal of the Controlled Release Society 2019 Jan 28;294:17-26
A Neuron-Glial Trans-Signaling Cascade Mediates LRRK2-Induced Neurodegeneration.
Maksoud E, Liao EH, Haghighi AP
Cell reports 2019 Feb 12;26(7):1774-1786.e4
Cell reports 2019 Feb 12;26(7):1774-1786.e4
The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis.
Mouchiroud M, Camiré É, Aldow M, Caron A, Jubinville É, Turcotte L, Kaci I, Beaulieu MJ, Roy C, Labbé SM, Varin TV, Gélinas Y, Lamothe J, Trottier J, Mitchell PL, Guénard F, Festuccia WT, Joubert P, Rose CF, Karvellas CJ, Barbier O, Morissette MC, Marette A, Laplante M
Molecular metabolism 2019 Dec;30:184-191
Molecular metabolism 2019 Dec;30:184-191
Palm Fruit Bioactives augment expression of Tyrosine Hydroxylase in the Nile Grass Rat basal ganglia and alter the colonic microbiome.
Weinberg RP, Koledova VV, Subramaniam A, Schneider K, Artamonova A, Sambanthamurthi R, Hayes KC, Sinskey AJ, Rha C
Scientific reports 2019 Dec 9;9(1):18625
Scientific reports 2019 Dec 9;9(1):18625
Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression.
Kamiya A, Hayama Y, Kato S, Shimomura A, Shimomura T, Irie K, Kaneko R, Yanagawa Y, Kobayashi K, Ochiya T
Nature neuroscience 2019 Aug;22(8):1289-1305
Nature neuroscience 2019 Aug;22(8):1289-1305
The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.
Mouchiroud M, Camiré É, Aldow M, Caron A, Jubinville É, Turcotte L, Kaci I, Beaulieu MJ, Roy C, Labbé SM, Varin TV, Gélinas Y, Lamothe J, Trottier J, Mitchell PL, Guénard F, Festuccia WT, Joubert P, Rose CF, Karvellas CJ, Barbier O, Morissette MC, Marette A, Laplante M
JCI insight 2019 Aug 8;4(15)
JCI insight 2019 Aug 8;4(15)
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Kim S, Kwon SH, Kam TI, Panicker N, Karuppagounder SS, Lee S, Lee JH, Kim WR, Kook M, Foss CA, Shen C, Lee H, Kulkarni S, Pasricha PJ, Lee G, Pomper MG, Dawson VL, Dawson TM, Ko HS
Neuron 2019 Aug 21;103(4):627-641.e7
Neuron 2019 Aug 21;103(4):627-641.e7
Tyrosine hydroxylase-immunoreactive neurons in the mushroom body of the field cricket, Gryllus bimaculatus.
Hamanaka Y, Mizunami M
Cell and tissue research 2019 Apr;376(1):97-111
Cell and tissue research 2019 Apr;376(1):97-111
Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells.
Bechmann N, Poser I, Seifert V, Greunke C, Ullrich M, Qin N, Walch A, Peitzsch M, Robledo M, Pacak K, Pietzsch J, Richter S, Eisenhofer G
Cancers 2019 Apr 28;11(5)
Cancers 2019 Apr 28;11(5)
Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress.
Kim H, Park J, Leem H, Cho M, Yoon JH, Maeng HJ, Lee Y
International journal of molecular sciences 2019 Apr 10;20(7)
International journal of molecular sciences 2019 Apr 10;20(7)
Characterization of the Sexually Dimorphic fruitless Neurons That Regulate Copulation Duration.
Jois S, Chan YB, Fernandez MP, Leung AK
Frontiers in physiology 2018;9:780
Frontiers in physiology 2018;9:780
Neural Control of Startle-Induced Locomotion by the Mushroom Bodies and Associated Neurons in Drosophila.
Sun J, Xu AQ, Giraud J, Poppinga H, Riemensperger T, Fiala A, Birman S
Frontiers in systems neuroscience 2018;12:6
Frontiers in systems neuroscience 2018;12:6
An exercise in brain genoarchitectonics: Analysis of AZIN2-Lacz expressing neuronal populations in the mouse hindbrain.
Martinez-de-la-Torre M, Lambertos A, Peñafiel R, Puelles L
Journal of neuroscience research 2018 Sep;96(9):1490-1517
Journal of neuroscience research 2018 Sep;96(9):1490-1517
Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease.
Kim D, Yoo JM, Hwang H, Lee J, Lee SH, Yun SP, Park MJ, Lee M, Choi S, Kwon SH, Lee S, Kwon SH, Kim S, Park YJ, Kinoshita M, Lee YH, Shin S, Paik SR, Lee SJ, Lee S, Hong BH, Ko HS
Nature nanotechnology 2018 Sep;13(9):812-818
Nature nanotechnology 2018 Sep;13(9):812-818
Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65.
Hudry E, Andres-Mateos E, Lerner EP, Volak A, Cohen O, Hyman BT, Maguire CA, Vandenberghe LH
Molecular therapy. Methods & clinical development 2018 Sep 21;10:197-209
Molecular therapy. Methods & clinical development 2018 Sep 21;10:197-209
Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting.
Williams ET, Glauser L, Tsika E, Jiang H, Islam S, Moore DJ
Human molecular genetics 2018 Sep 15;27(18):3189-3205
Human molecular genetics 2018 Sep 15;27(18):3189-3205
Behavioral and neurochemical responses derived from dopaminergic intrastriatal grafts in hemiparkinsonian rats engaged in a novel motor task.
Bhupal PK, Anderson KA, Shall GP, Lynn JD, Hoolsema KS, Rossignol J, Dunbar GL, Sandstrom MI
Journal of neuroscience methods 2018 Sep 1;307:149-163
Journal of neuroscience methods 2018 Sep 1;307:149-163
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.
Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J 3rd, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G, Studer L
Nature communications 2018 Oct 19;9(1):4345
Nature communications 2018 Oct 19;9(1):4345
Long-term immunosuppression for CNS mouse xenotransplantation: Effects on nigrostriatal neurodegeneration and neuroprotective carotid body cell therapy.
Villadiego J, Romo-Madero S, García-Swinburn R, Suárez-Luna N, Bermejo-Navas A, Echevarría M, Toledo-Aral JJ
Xenotransplantation 2018 Nov;25(6):e12410
Xenotransplantation 2018 Nov;25(6):e12410
Parkinson's Disease Associated α-Synuclein Familial Mutants Promote Dopaminergic Neuronal Death in Drosophila melanogaster.
Mohite GM, Dwivedi S, Das S, Kumar R, Paluri S, Mehra S, Ruhela N, S A, Jha NN, Maji SK
ACS chemical neuroscience 2018 Nov 21;9(11):2628-2638
ACS chemical neuroscience 2018 Nov 21;9(11):2628-2638
A novel extended form of alpha-synuclein 3'UTR in the human brain.
Je G, Guhathakurta S, Yun SP, Ko HS, Kim YS
Molecular brain 2018 May 25;11(1):29
Molecular brain 2018 May 25;11(1):29
Correction: HIF-2α is essential for carotid body development and function.
Macias D, Cowburn AS, Torres-Torrelo H, Ortega-Sáenz P, López-Barneo J, Johnson R
eLife 2018 Jun 4;7
eLife 2018 Jun 4;7
PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies.
Fielding JW, Hodson EJ, Cheng X, Ferguson DJP, Eckardt L, Adam J, Lip P, Maton-Howarth M, Ratnayaka I, Pugh CW, Buckler KJ, Ratcliffe PJ, Bishop T
The Journal of physiology 2018 Jun 19;596(18):4393-412
The Journal of physiology 2018 Jun 19;596(18):4393-412
The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model.
Lee S, Kim S, Park YJ, Yun SP, Kwon SH, Kim D, Kim DY, Shin JS, Cho DJ, Lee GY, Ju HS, Yun HJ, Park JH, Kim WR, Jung EA, Lee S, Ko HS
Human molecular genetics 2018 Jul 1;27(13):2344-2356
Human molecular genetics 2018 Jul 1;27(13):2344-2356
GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers.
Kim S, Yun SP, Lee S, Umanah GE, Bandaru VVR, Yin X, Rhee P, Karuppagounder SS, Kwon SH, Lee H, Mao X, Kim D, Pandey A, Lee G, Dawson VL, Dawson TM, Ko HS
Proceedings of the National Academy of Sciences of the United States of America 2018 Jan 23;115(4):798-803
Proceedings of the National Academy of Sciences of the United States of America 2018 Jan 23;115(4):798-803
PARIS reprograms glucose metabolism by HIF-1α induction in dopaminergic neurodegeneration.
Kang H, Jo A, Kim H, Khang R, Lee JY, Kim H, Park CH, Choi JY, Lee Y, Shin JH
Biochemical and biophysical research communications 2018 Jan 22;495(4):2498-2504
Biochemical and biophysical research communications 2018 Jan 22;495(4):2498-2504
Primary fibroblast co-culture stimulates growth and metabolism in Sdhb-impaired mouse pheochromocytoma MTT cells.
Richter S, D'Antongiovanni V, Martinelli S, Bechmann N, Riverso M, Poitz DM, Pacak K, Eisenhofer G, Mannelli M, Rapizzi E
Cell and tissue research 2018 Dec;374(3):473-485
Cell and tissue research 2018 Dec;374(3):473-485
Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model.
Salama M, Elhussiny M, Magdy A, Omran AG, Alsayed A, Ashry R, Mohamed W
Metabolic brain disease 2018 Apr;33(2):583-587
Metabolic brain disease 2018 Apr;33(2):583-587
D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model.
Kim D, Hwang H, Choi S, Kwon SH, Lee S, Park JH, Kim S, Ko HS
Acta neuropathologica communications 2018 Apr 27;6(1):32
Acta neuropathologica communications 2018 Apr 27;6(1):32
Cocaine- and Amphetamine-Regulated Transcript Peptide (CART) Alleviates MK-801-Induced Schizophrenic Dementia-Like Symptoms.
Borkar CD, Bharne AP, Nagalakshmi B, Sakharkar AJ, Subhedar NK, Kokare DM
Neuroscience 2018 Apr 1;375:94-107
Neuroscience 2018 Apr 1;375:94-107
Striatal But Not Extrastriatal Dopamine Receptors Are Critical to Dopaminergic Motor Stimulation.
Wang Y, Zhou FM
Frontiers in pharmacology 2017;8:935
Frontiers in pharmacology 2017;8:935
Whole genome expression profiling associates activation of unfolded protein response with impaired production and release of epinephrine after recurrent hypoglycemia.
Kim JL, La Gamma EF, Estabrook T, Kudrick N, Nankova BB
PloS one 2017;12(2):e0172789
PloS one 2017;12(2):e0172789
Gene expression analyses reveal metabolic specifications in acute O(2) -sensing chemoreceptor cells.
Gao L, Bonilla-Henao V, García-Flores P, Arias-Mayenco I, Ortega-Sáenz P, López-Barneo J
The Journal of physiology 2017 Sep 15;595(18):6091-6120
The Journal of physiology 2017 Sep 15;595(18):6091-6120
Cardiovascular adaptation to hypoxia and the role of peripheral resistance.
Cowburn AS, Macias D, Summers C, Chilvers ER, Johnson RS
eLife 2017 Oct 19;6
eLife 2017 Oct 19;6
Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology.
Xiong Y, Neifert S, Karuppagounder SS, Stankowski JN, Lee BD, Grima JC, Chen G, Ko HS, Lee Y, Swing D, Tessarollo L, Dawson TM, Dawson VL
eNeuro 2017 Mar-Apr;4(2)
eNeuro 2017 Mar-Apr;4(2)
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M
Cell metabolism 2017 Jun 6;25(6):1390-1399.e6
Cell metabolism 2017 Jun 6;25(6):1390-1399.e6
Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K
Experimental neurology 2017 Jul;293:1-12
Experimental neurology 2017 Jul;293:1-12
Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection.
Kang H, Khang R, Ham S, Jeong GR, Kim H, Jo M, Lee BD, Lee YI, Jo A, Park C, Kim H, Seo J, Paek SH, Lee YS, Choi JY, Lee Y, Shin JH
Oncotarget 2017 Jul 25;8(30):48603-48618
Oncotarget 2017 Jul 25;8(30):48603-48618
Assessment of the acquisition of executive function during the transition from adolescence to adulthood in male and female mice.
Shepard R, Beckett E, Coutellier L
Developmental cognitive neuroscience 2017 Dec;28:29-40
Developmental cognitive neuroscience 2017 Dec;28:29-40
Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models.
Kim H, Ham S, Lee JY, Jo A, Lee GH, Lee YS, Cho M, Shin HM, Kim D, Pletnikova O, Troncoso JC, Shin JH, Lee YI, Lee Y
Oncotarget 2017 Dec 5;8(63):106721-106739
Oncotarget 2017 Dec 5;8(63):106721-106739
Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation.
Awad O, Panicker LM, Deranieh RM, Srikanth MP, Brown RA, Voit A, Peesay T, Park TS, Zambidis ET, Feldman RA
Stem cell reports 2017 Dec 12;9(6):1853-1867
Stem cell reports 2017 Dec 12;9(6):1853-1867
Nociceptive DRG neurons express muscle lim protein upon axonal injury.
Levin E, Andreadaki A, Gobrecht P, Bosse F, Fischer D
Scientific reports 2017 Apr 4;7(1):643
Scientific reports 2017 Apr 4;7(1):643
Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body.
Annese V, Navarro-Guerrero E, Rodríguez-Prieto I, Pardal R
Cell reports 2017 Apr 18;19(3):471-478
Cell reports 2017 Apr 18;19(3):471-478
Dopamine- and Tyrosine Hydroxylase-Immunoreactive Neurons in the Brain of the American Cockroach, Periplaneta americana.
Hamanaka Y, Minoura R, Nishino H, Miura T, Mizunami M
PloS one 2016;11(8):e0160531
PloS one 2016;11(8):e0160531
Olfactory Sensory Activity Modulates Microglial-Neuronal Interactions during Dopaminergic Cell Loss in the Olfactory Bulb.
Grier BD, Belluscio L, Cheetham CE
Frontiers in cellular neuroscience 2016;10:178
Frontiers in cellular neuroscience 2016;10:178
Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines.
Januchowski R, Wojtowicz K, Sterzyſska K, Sosiſska P, Andrzejewska M, Zawierucha P, Nowicki M, Zabel M
The international journal of biochemistry & cell biology 2016 Sep;78:248-259
The international journal of biochemistry & cell biology 2016 Sep;78:248-259
LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity.
Karuppagounder SS, Xiong Y, Lee Y, Lawless MC, Kim D, Nordquist E, Martin I, Ge P, Brahmachari S, Jhaldiyal A, Kumar M, Andrabi SA, Dawson TM, Dawson VL
Journal of chemical neuroanatomy 2016 Oct;76(Pt B):90-97
Journal of chemical neuroanatomy 2016 Oct;76(Pt B):90-97
Involvement of catecholaminergic neurons in motor innervation of striated muscle in the mouse esophagus.
van der Keylen P, Garreis F, Steigleder R, Sommer D, Neuhuber WL, Wörl J
Histochemistry and cell biology 2016 May;145(5):573-85
Histochemistry and cell biology 2016 May;145(5):573-85
Chronic social isolation enhances reproduction in the monogamous prairie vole (Microtus ochrogaster).
Perry AN, Carter CS, Cushing BS
Psychoneuroendocrinology 2016 Jun;68:20-8
Psychoneuroendocrinology 2016 Jun;68:20-8
Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease.
Ahuja M, Ammal Kaidery N, Yang L, Calingasan N, Smirnova N, Gaisin A, Gaisina IN, Gazaryan I, Hushpulian DM, Kaddour-Djebbar I, Bollag WB, Morgan JC, Ratan RR, Starkov AA, Beal MF, Thomas B
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Jun 8;36(23):6332-51
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Jun 8;36(23):6332-51
Thiazine Red(+) platelet inclusions in Cerebral Blood Vessels are first signs in an Alzheimer's Disease mouse model.
Kniewallner KM, Wenzel D, Humpel C
Scientific reports 2016 Jun 27;6:28447
Scientific reports 2016 Jun 27;6:28447
Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice.
Xue X, Yang JY, He Y, Wang LR, Liu P, Yu LS, Bi GH, Zhu MM, Liu YY, Xiang RW, Yang XT, Fan XY, Wang XM, Qi J, Zhang HJ, Wei T, Cui W, Ge GL, Xi ZX, Wu CF, Liang XJ
Nature nanotechnology 2016 Jul;11(7):613-20
Nature nanotechnology 2016 Jul;11(7):613-20
Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons.
Jiang H, Kang SU, Zhang S, Karuppagounder S, Xu J, Lee YK, Kang BG, Lee Y, Zhang J, Pletnikova O, Troncoso JC, Pirooznia S, Andrabi SA, Dawson VL, Dawson TM
eNeuro 2016 Jul-Aug;3(4)
eNeuro 2016 Jul-Aug;3(4)
Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway.
Bains M, Roberts JL
Neuroscience letters 2016 Jan 1;610:79-85
Neuroscience letters 2016 Jan 1;610:79-85
Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone.
Javed H, Azimullah S, Abul Khair SB, Ojha S, Haque ME
BMC neuroscience 2016 Aug 22;17(1):58
BMC neuroscience 2016 Aug 22;17(1):58
HIF2α-arginase axis is essential for the development of pulmonary hypertension.
Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS
Proceedings of the National Academy of Sciences of the United States of America 2016 Aug 2;113(31):8801-6
Proceedings of the National Academy of Sciences of the United States of America 2016 Aug 2;113(31):8801-6
Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model.
Lin CY, Hsieh HY, Chen CM, Wu SR, Tsai CH, Huang CY, Hua MY, Wei KC, Yeh CK, Liu HL
Journal of controlled release : official journal of the Controlled Release Society 2016 Aug 10;235:72-81
Journal of controlled release : official journal of the Controlled Release Society 2016 Aug 10;235:72-81
Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.
Stevens DA, Lee Y, Kang HC, Lee BD, Lee YI, Bower A, Jiang H, Kang SU, Andrabi SA, Dawson VL, Shin JH, Dawson TM
Proceedings of the National Academy of Sciences of the United States of America 2015 Sep 15;112(37):11696-701
Proceedings of the National Academy of Sciences of the United States of America 2015 Sep 15;112(37):11696-701
Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease.
Liu W, Li Y, Jalewa J, Saunders-Wood T, Li L, Hölscher C
European journal of pharmacology 2015 Oct 15;765:284-90
European journal of pharmacology 2015 Oct 15;765:284-90
Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.
Tsika E, Nguyen AP, Dusonchet J, Colin P, Schneider BL, Moore DJ
Neurobiology of disease 2015 May;77:49-61
Neurobiology of disease 2015 May;77:49-61
PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine.
Kuo SY, Wu CL, Hsieh MY, Lin CT, Wen RK, Chen LC, Chen YH, Yu YW, Wang HD, Su YJ, Lin CJ, Yang CY, Guan HY, Wang PY, Lan TH, Fu TF
Nature communications 2015 Jun 30;6:7490
Nature communications 2015 Jun 30;6:7490
Similar L-dopa-stimulated motor activity in mice with adult-onset 6-hydroxydopamine-induced symmetric dopamine denervation and in transcription factor Pitx3 null mice with perinatal-onset symmetric dopamine denervation.
Li L, Sagot B, Zhou FM
Brain research 2015 Jul 30;1615:12-21
Brain research 2015 Jul 30;1615:12-21
Mitochondrial complex I defects increase ubiquitin in substantia nigra.
Song L, Cortopassi G
Brain research 2015 Jan 12;1594:82-91
Brain research 2015 Jan 12;1594:82-91
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
Tsika E, Glauser L, Moser R, Fiser A, Daniel G, Sheerin UM, Lees A, Troncoso JC, Lewis PA, Bandopadhyay R, Schneider BL, Moore DJ
Human molecular genetics 2014 Sep 1;23(17):4621-38
Human molecular genetics 2014 Sep 1;23(17):4621-38
Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.
Tsika E, Kannan M, Foo CS, Dikeman D, Glauser L, Gellhaar S, Galter D, Knott GW, Dawson TM, Dawson VL, Moore DJ
Neurobiology of disease 2014 Nov;71:345-58
Neurobiology of disease 2014 Nov;71:345-58
Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue.
Grünewald A, Lax NZ, Rocha MC, Reeve AK, Hepplewhite PD, Rygiel KA, Taylor RW, Turnbull DM
Journal of neuroscience methods 2014 Jul 30;232:143-9
Journal of neuroscience methods 2014 Jul 30;232:143-9
An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia.
Platero-Luengo A, González-Granero S, Durán R, Díaz-Castro B, Piruat JI, García-Verdugo JM, Pardal R, López-Barneo J
Cell 2014 Jan 16;156(1-2):291-303
Cell 2014 Jan 16;156(1-2):291-303
Age-mediated transcriptomic changes in adult mouse substantia nigra.
Gao L, Hidalgo-Figueroa M, Escudero LM, Díaz-Martín J, López-Barneo J, Pascual A
PloS one 2013;8(4):e62456
PloS one 2013;8(4):e62456
Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.
Lee Y, Karuppagounder SS, Shin JH, Lee YI, Ko HS, Swing D, Jiang H, Kang SU, Lee BD, Kang HC, Kim D, Tessarollo L, Dawson VL, Dawson TM
Nature neuroscience 2013 Oct;16(10):1392-400
Nature neuroscience 2013 Oct;16(10):1392-400
Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia.
Johansson JU, Pradhan S, Lokteva LA, Woodling NS, Ko N, Brown HD, Wang Q, Loh C, Cekanaviciute E, Buckwalter M, Manning-Bog AB, Andreasson KI
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Oct 2;33(40):16016-32
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Oct 2;33(40):16016-32
Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice.
Wei W, Li L, Yu G, Ding S, Li C, Zhou FM
Journal of neurophysiology 2013 Nov;110(9):2203-16
Journal of neurophysiology 2013 Nov;110(9):2203-16
Innervation pattern of the preocular human central retinal artery.
Bergua A, Kapsreiter M, Neuhuber WL, Reitsamer HA, Schrödl F
Experimental eye research 2013 May;110:142-7
Experimental eye research 2013 May;110:142-7
Neuroprotective and reparative effects of carotid body grafts in a chronic MPTP model of Parkinson's disease.
Muñoz-Manchado AB, Villadiego J, Suárez-Luna N, Bermejo-Navas A, Garrido-Gil P, Labandeira-García JL, Echevarría M, López-Barneo J, Toledo-Aral JJ
Neurobiology of aging 2013 Mar;34(3):902-15
Neurobiology of aging 2013 Mar;34(3):902-15
Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model.
Amschl D, Neddens J, Havas D, Flunkert S, Rabl R, Römer H, Rockenstein E, Masliah E, Windisch M, Hutter-Paier B
BMC neuroscience 2013 Jan 9;14:6
BMC neuroscience 2013 Jan 9;14:6
Cellular properties and chemosensory responses of the human carotid body.
Ortega-Sáenz P, Pardal R, Levitsky K, Villadiego J, Muñoz-Manchado AB, Durán R, Bonilla-Henao V, Arias-Mayenco I, Sobrino V, Ordóñez A, Oliver M, Toledo-Aral JJ, López-Barneo J
The Journal of physiology 2013 Dec 15;591(24):6157-73
The Journal of physiology 2013 Dec 15;591(24):6157-73
Severe nigrostriatal degeneration without clinical parkinsonism in patients with polymerase gamma mutations.
Tzoulis C, Tran GT, Schwarzlmüller T, Specht K, Haugarvoll K, Balafkan N, Lilleng PK, Miletic H, Biermann M, Bindoff LA
Brain : a journal of neurology 2013 Aug;136(Pt 8):2393-404
Brain : a journal of neurology 2013 Aug;136(Pt 8):2393-404
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Palin EJ, Paetau A, Suomalainen A
Brain : a journal of neurology 2013 Aug;136(Pt 8):2379-92
Brain : a journal of neurology 2013 Aug;136(Pt 8):2379-92
PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice: old switch, new target.
Ahmad AS, Maruyama T, Narumiya S, Doré S
Neurotoxicity research 2013 Apr;23(3):260-6
Neurotoxicity research 2013 Apr;23(3):260-6
Single dopaminergic neurons that modulate aggression in Drosophila.
Alekseyenko OV, Chan YB, Li R, Kravitz EA
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 9;110(15):6151-6
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 9;110(15):6151-6
Parallel dopamine D1 receptor activity dependence of l-Dopa-induced normal movement and dyskinesia in mice.
Li L, Zhou FM
Neuroscience 2013 Apr 16;236:66-76
Neuroscience 2013 Apr 16;236:66-76
Adaptive alternative splicing correlates with less environmental risk of parkinsonism.
Benmoyal-Segal L, Soreq L, Ben-Shaul Y, Ben-Ari S, Ben-Moshe T, Aviel S, Bergman H, Soreq H
Neuro-degenerative diseases 2012;9(2):87-98
Neuro-degenerative diseases 2012;9(2):87-98
Development and characterization of a new Parkinson's disease model resulting from impaired autophagy.
Ahmed I, Liang Y, Schools S, Dawson VL, Dawson TM, Savitt JM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 14;32(46):16503-9
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 14;32(46):16503-9
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.
Daher JP, Pletnikova O, Biskup S, Musso A, Gellhaar S, Galter D, Troncoso JC, Lee MK, Dawson TM, Dawson VL, Moore DJ
Human molecular genetics 2012 Jun 1;21(11):2420-31
Human molecular genetics 2012 Jun 1;21(11):2420-31
GDNF is predominantly expressed in the PV+ neostriatal interneuronal ensemble in normal mouse and after injury of the nigrostriatal pathway.
Hidalgo-Figueroa M, Bonilla S, Gutiérrez F, Pascual A, López-Barneo J
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jan 18;32(3):864-72
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jan 18;32(3):864-72
Differential impairment of catecholaminergic cell maturation and survival by genetic mitochondrial complex II dysfunction.
Díaz-Castro B, Pintado CO, García-Flores P, López-Barneo J, Piruat JI
Molecular and cellular biology 2012 Aug;32(16):3347-57
Molecular and cellular biology 2012 Aug;32(16):3347-57
Expression of the neuregulin receptor ErbB4 in the brain of the rhesus monkey (Macaca mulatta).
Neddens J, Buonanno A
PloS one 2011;6(11):e27337
PloS one 2011;6(11):e27337
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.
Herzig MC, Kolly C, Persohn E, Theil D, Schweizer T, Hafner T, Stemmelen C, Troxler TJ, Schmid P, Danner S, Schnell CR, Mueller M, Kinzel B, Grevot A, Bolognani F, Stirn M, Kuhn RR, Kaupmann K, van der Putten PH, Rovelli G, Shimshek DR
Human molecular genetics 2011 Nov 1;20(21):4209-23
Human molecular genetics 2011 Nov 1;20(21):4209-23
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, Troconso JC, Dawson VL, Dawson TM
Cell 2011 Mar 4;144(5):689-702
Cell 2011 Mar 4;144(5):689-702
Brain stem catecholamines circuitry: activation by alcohol and role in the hypothalamic-pituitary-adrenal response to this drug.
Lee S, Craddock Z, Rivier C
Journal of neuroendocrinology 2011 Jun;23(6):531-41
Journal of neuroendocrinology 2011 Jun;23(6):531-41
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
Ramonet D, Daher JP, Lin BM, Stafa K, Kim J, Banerjee R, Westerlund M, Pletnikova O, Glauser L, Yang L, Liu Y, Swing DA, Beal MF, Troncoso JC, McCaffery JM, Jenkins NA, Copeland NG, Galter D, Thomas B, Lee MK, Dawson TM, Dawson VL, Moore DJ
PloS one 2011 Apr 6;6(4):e18568
PloS one 2011 Apr 6;6(4):e18568
Targeted manipulation of serotonergic neurotransmission affects the escalation of aggression in adult male Drosophila melanogaster.
Alekseyenko OV, Lee C, Kravitz EA
PloS one 2010 May 24;5(5):e10806
PloS one 2010 May 24;5(5):e10806
Effects of IL-6 secreted from astrocytes on the survival of dopaminergic neurons in lipopolysaccharide-induced inflammation.
Li XZ, Bai LM, Yang YP, Luo WF, Hu WD, Chen JP, Mao CJ, Liu CF
Neuroscience research 2009 Nov;65(3):252-8
Neuroscience research 2009 Nov;65(3):252-8
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.
Venderova K, Kabbach G, Abdel-Messih E, Zhang Y, Parks RJ, Imai Y, Gehrke S, Ngsee J, Lavoie MJ, Slack RS, Rao Y, Zhang Z, Lu B, Haque ME, Park DS
Human molecular genetics 2009 Nov 15;18(22):4390-404
Human molecular genetics 2009 Nov 15;18(22):4390-404
Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
Andres-Mateos E, Mejias R, Sasaki M, Li X, Lin BM, Biskup S, Zhang L, Banerjee R, Thomas B, Yang L, Liu G, Beal MF, Huso DL, Dawson TM, Dawson VL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Dec 16;29(50):15846-50
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Dec 16;29(50):15846-50
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase.
Andres-Mateos E, Perier C, Zhang L, Blanchard-Fillion B, Greco TM, Thomas B, Ko HS, Sasaki M, Ischiropoulos H, Przedborski S, Dawson TM, Dawson VL
Proceedings of the National Academy of Sciences of the United States of America 2007 Sep 11;104(37):14807-12
Proceedings of the National Academy of Sciences of the United States of America 2007 Sep 11;104(37):14807-12
Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity.
Kunz TH, Scott M, Ittner LM, Fischer JA, Born W, Vogel J
American journal of physiology. Heart and circulatory physiology 2007 Oct;293(4):H2155-60
American journal of physiology. Heart and circulatory physiology 2007 Oct;293(4):H2155-60
Adaptive acetylcholinesterase splicing patterns attenuate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice.
Ben-Shaul Y, Benmoyal-Segal L, Ben-Ari S, Bergman H, Soreq H
The European journal of neuroscience 2006 Jun;23(11):2915-22
The European journal of neuroscience 2006 Jun;23(11):2915-22
Loss of locus coeruleus neurons and reduced startle in parkin null mice.
Von Coelln R, Thomas B, Savitt JM, Lim KL, Sasaki M, Hess EJ, Dawson VL, Dawson TM
Proceedings of the National Academy of Sciences of the United States of America 2004 Jul 20;101(29):10744-9
Proceedings of the National Academy of Sciences of the United States of America 2004 Jul 20;101(29):10744-9
A hypothalamic-testicular neural pathway is influenced by brain catecholamines, but not testicular blood flow.
Selvage DJ, Lee SY, Parsons LH, Seo DO, Rivier CL
Endocrinology 2004 Apr;145(4):1750-9
Endocrinology 2004 Apr;145(4):1750-9
Central pathways in the pons and midbrain involved in cardiac sympathoexcitatory reflexes in cats.
Guo Z-, Li P, Longhurst JC
Neuroscience 2002;113(2):435-47
Neuroscience 2002;113(2):435-47
Central pathways in the pons and midbrain involved in cardiac sympathoexcitatory reflexes in cats.
Guo Z-, Li P, Longhurst JC
Neuroscience 2002;113(2):435-47
Neuroscience 2002;113(2):435-47
Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group.
Nocjar C, Roth BL, Pehek EA
Neuroscience 2002;111(1):163-76
Neuroscience 2002;111(1):163-76
Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group.
Nocjar C, Roth BL, Pehek EA
Neuroscience 2002;111(1):163-76
Neuroscience 2002;111(1):163-76
Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat.
Guo ZL, Lai HC, Longhurst JC
Brain research 2002 Jan 18;925(1):55-66
Brain research 2002 Jan 18;925(1):55-66
Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat.
Guo ZL, Lai HC, Longhurst JC
Brain research 2002 Jan 18;925(1):55-66
Brain research 2002 Jan 18;925(1):55-66
Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia.
Quick KL, Dugan LL
Annals of neurology 2001 May;49(5):627-35
Annals of neurology 2001 May;49(5):627-35
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Simple Western: Tyrosine Hydroxylase Antibody [NB300-109] - Simple Western lane view shows a specific band for Tyrosine Hydroxylase in 0.2 mg/mL of PC-12 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Tyrosine Hydroxylase Antibody [NB300-109] - Western blot of 10 ug of rat striatal lysate showing specific immunolabeling of the ~60 kDa tyrosine hydroxylase protein.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Tyrosine Hydroxylase Antibody [NB300-109] - Western blot analysis confirms activation of UPR following Hotel protein lysates from the right adrenal medulla of saline (2RS) and RH groups (2RH) were subjected to Western blot analyses as described in methods. Proteins were separated by SDS-PAGE, electroblotted and the membranes were sequentially probed with antibodies specific to Grp78, Derlin1, TH and GAPDH. Similar results were obtained in two separate replicate experiments. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0172789), licensed under a CC-BY licence.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: Tyrosine Hydroxylase Antibody [NB300-109] - Immunohistochemical staining of retina tissue using TH antibody, NB300-109.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Tyrosine Hydroxylase Antibody [NB300-109] - Immunohistochemical analysis of a formalin fixed and paraffin embedded rat brain tissue section using Tyrosine Hydroxylase antibody at 1:5000 dilution. The primary antibody binding to its antigen was detected using HRP anti-Polyvalent ready-to-use kit (Ultratek, 35368) with DAB (brown) and the sections were further counterstained using hematoxylin. Isotype control section was incubated with Rabbit IgG Isotype Control antibody and was processed under the same assay conditions. Tyrosine hydroxylase staining (brown) was observed in the test samples only and the signal was specifically localized to the neuronal cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: Tyrosine Hydroxylase Antibody [NB300-109] - Tyrosine hydroxylase immunoreactivity in the mushroom body. All panels show a right brain hemisphere (dorsal to the top, medial to the right), except panels M-O (posterior to the top). Tyrosine hydroxylase (TH) immunoreactivity is shown in magenta (A, D, G, J, M) and synapsin immunoreactivity in green (B, E, H, K, N). Corresponding merged images in C, F, I, L, O. Scale bars = 100 um. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0160531), licensed under a CC-BY licence.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: Tyrosine Hydroxylase Antibody [NB300-109] - Tyrosine hydroxylase immunoreactivity in the central complex and the lateral accessory lobe. A-D: Frontal sections (immunoperoxidase preparations, dorsal to the top). E: Horizontal section (immunofluorescent preparation, posterior to the top). Scale bars = 100 um. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0160531), licensed under a CC-BY licence.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry Whole-Mount: Tyrosine Hydroxylase Antibody [NB300-109] - Immunostaining of whole-mount Drosophila brains using NB300-109 at 1:500 dilution. The tyrosine hydroxylase antibody worked really well and produced a bright staining with almost no background. Data courtesy of Dr. Olga Alekseenko, Neurobiology Dept. Harvard Medical School.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry Whole-Mount: Tyrosine Hydroxylase Antibody [NB300-109] - Immunohistochemical analysis of tyrosine hydroxylase in rat mesenteric artery-whole. ICC/IF image submitted by a verified customer review.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Frozen: Tyrosine Hydroxylase Antibody [NB300-109] - 10x Magnification cryo-sections mouse: primary antibody: anti-rb TH: 1:500; o.n. secondary antibody: 1:500 dk-anti-rb DyLight488. IHC-Fr image submitted by a verified customer review.
