NAPSA

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]

Description

Napsin A aspartic peptidase

Tissue specificity

Tissue enriched (lung)

Predicted location

Secreted in other tissues

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (50358477 - 50365830)

Ensembl ID

ENSG00000131400  (ver. 103.38)

Orthologs

Mouse Napsa: ENSMUSG00000002204

UniProt

O96009

neXtProt

NX_O96009

Human splice variants
Mouse splice variants

Protein structure