MAPK1

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

Description

Mitogen-activated protein kinase 1

Tissue specificity

Low tissue specificity

Subcell location

Nuclear speckles, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

22 (21759657 - 21867680)

Ensembl ID

ENSG00000100030  (ver. 103.38)

Orthologs

Mouse Mapk1: ENSMUSG00000063358

UniProt

P28482

neXtProt

NX_P28482

Human splice variants
Mouse splice variants

Protein structure