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Protein structure
PLCG1
Phospholipase C gamma 1NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Abnova Corporation |  H00005335-M01 |
1 references | Monoclonal |
WB
EL
ICC
PLA
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| antibodies-online | ABIN4880946 |
Monoclonal |
WB
EL
ICC
IHC
FC
|
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| Novus Biologicals | H00005335-M01 |
1 references | Monoclonal |
WB
EL
ICC
PLA
|
|
| Invitrogen Antibodies | 44-696G |
18 references | Polyclonal |
WB
ICC
IHC
OA
|
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| Cell Signaling Technology, Inc | 8713 |
Monoclonal |
WB
ICC
IP
IHC
FC
|
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