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Protein structure
BAP1
BRCA1 associated protein 1hucep-6, KIAA0272, UCHL2
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
Top validated antibodies |
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| Proteintech Group |  10398-1-AP |
1 references | Polyclonal |
WB
EL
IP
IHC
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| antibodies-online | ABIN258775 |
1 references | Monoclonal |
WB
FC
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| Novus Biologicals | NB110-60521 |
1 references | Monoclonal |
WB
FC
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| Biorbyt | orb1431655 |
Polyclonal |
WB
ICC
IHC
FC
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| Invitrogen Antibodies | PA5-12061 |
1 references | Polyclonal |
WB
FC
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