633001

antibody from BioLegend

Targeting: CBL c-Cbl, CBL2, RNF55

Western blot (Data presented on provider website)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

633001

Provider

BioLegend

Proper citation

BioLegend Cat#633001, RRID:AB_2070439

Product name

Purified anti-Cbl

Antibody type

Polyclonal

Antigen

peptide mapping to the carboxy terminal domain of human Cbl

Description

The proto-oncogene c-Cbl was initially identified as the cellular homologue of v-Cbl oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. The Cbl family comprises three mammalian proteins, c-Cbl, Cbl-b, and Cbl-3; among these, c-Cbl and Cbl-b are expressed in hemopoietic cells, whereas Cbl-3 is expressed only in epithelial tissues. Cbl proteins can function as E3 ubiquitin (Ub) ligases, and in more recent studies Cbl has been implicated in the negative regulation of various RTKs.The poly6330 antibody has been shown to be useful for western blotting, immunoprecipitation, and immunohistochemistry of human, mouse, and rat Cbl protein.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Vial size

125 µl

Storage

The antibody solution should be stored undiluted at 4°C. DO NOT FREEZE."