IL4R

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Description

Interleukin 4 receptor

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Plasma membrane, Centriolar satellite

Predicted location

Intracellular, Membrane, Secreted to blood

Protein family

Cancer-related genes
CD markers
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

16 (27313668 - 27364778)

Ensembl ID

ENSG00000077238  (ver. 103.38)

Orthologs

Mouse Il4ra: ENSMUSG00000030748

UniProt

P24394

neXtProt

NX_P24394

Human splice variants
Mouse splice variants

Protein structure