BS2646

antibody from Bioworld Technology, Inc
Targeting: PRKCSH G19P1, GIIB, PCLD, PLD1, VASAP-60
Provider product page for BS2646
Western blot
Immunocytochemistry

Antibody data

Product number
BS2646 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS2646, RRID:AB_1662615
Product name
Glucosidase IIÉÇ (K117) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 90-130 of Human Glucosidase IIÉÇ.
Description
Trimming of glucoses from N-linked core glycans on newly synthesized glycoproteins occurs sequentially through the action of Glucosidases I and II in the endoplasmic reticulum (ER). Glucosidase II is an ER-localized enzyme that contains Ï« and ÉÇ subunits (Glucosidase IIÏ« and Glucosidase IIÉÇ). The Ï« and ÉÇ subunits form a defined heterodimeric complex with a molecular weight about 161 kDa. Glucosidase IIÏ« is the catalyitc core of the enzyme and can function independently of the ÉÇ subunit. The sequence of Glucosidase IIÉÇ encodes protein rich in glutamic and aspartic acid with a putative ER retention signal (HDEL) at the C terminus. The phosphorylated form of Glucosidase IIÉÇ is localized in the plasma membrane and is highly expressed in FGF stimulated fibroblasts and epidermal carcinoma cells. Glucosidase IIÉÇ was first purified from a human carcinoma cell line as a potential substrate for protein kinase C. Through the HDEL signal at the C-terminus, Glucosidase IIÉÇ retains the complete complex in the ER.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PRKCSH protein structure - BS2646 shown in red.