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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Immunohistochemistry [1]
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- Product number
- NBP1-41050 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-41050, RRID:AB_2238994
- Product name
- Mouse Monoclonal SP-D Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified. This antibody detects porcine surfactant protein D (pSP-D), a 138kD member of the collectin family of proteins. Surfactant protein D is thought to play a significant role in the innate immune response against microorganisms within the lungs and at other mucosal surfaces. SP-D is a multifunctional protein which binds selectively to saccharides and lipids on microbial surfaces promoting antimicrobial responses and regulating surfactant lipid homeostasis. SP-D expression is induced in lung surfactant in response to aerogenous bacterial infection, and upon binding to bacteria, promotes phagocytosis and antigen presentation by dendritic cells. Recent studies suggest that pSP-D could serve as a serum biomarker specific for bronchopneumonia in pigs.
- Reactivity
- Mouse, Porcine
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.125 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Maternal high-fat diet is associated with impaired fetal lung development.
Purification, characterization and immunolocalization of porcine surfactant protein D.
Pulmonary infections in swine induce altered porcine surfactant protein D expression and localization to dendritic cells in bronchial-associated lymphoid tissue.
Mayor RS, Finch KE, Zehr J, Morselli E, Neinast MD, Frank AP, Hahner LD, Wang J, Rakheja D, Palmer BF, Rosenfeld CR, Savani RC, Clegg DJ
American journal of physiology. Lung cellular and molecular physiology 2015 Aug 15;309(4):L360-8
American journal of physiology. Lung cellular and molecular physiology 2015 Aug 15;309(4):L360-8
Purification, characterization and immunolocalization of porcine surfactant protein D.
Soerensen CM, Nielsen OL, Willis A, Heegaard PM, Holmskov U
Immunology 2005 Jan;114(1):72-82
Immunology 2005 Jan;114(1):72-82
Pulmonary infections in swine induce altered porcine surfactant protein D expression and localization to dendritic cells in bronchial-associated lymphoid tissue.
Soerensen CM, Holmskov U, Aalbaek B, Boye M, Heegaard PM, Nielsen OL
Immunology 2005 Aug;115(4):526-35
Immunology 2005 Aug;115(4):526-35
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: SP-D Antibody (1.7) [NBP1-41050] - Staining of frozen pig lung with Mouse anti pig Surfactant Protein D
