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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [44]
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- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- ABIN252468 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Cytochrome C, Somatic (CYCS) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse, Rat, Canine, Horse, Porcine, Rabbit
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 7H8-2C12
- Vial size
- 0.1 mg
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action.
miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1.
Curcumin conjugated with PLGA potentiates sustainability, anti-proliferative activity and apoptosis in human colon carcinoma cells.
Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells.
Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent.
Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells.
Tailor-made designer helical peptides that induce mitochondrion-mediated cell death without necrosis.
Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells.
Effects of CEES and LPS synergistically stimulate oxidative stress inactivates OGG1 signaling in macrophage cells.
Resveratrol induces apoptosis via a Bak-mediated intrinsic pathway in human lung adenocarcinoma cells.
Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice.
Synthesis and potential cytotoxic activity of new phenanthrylphenol-pyrrolobenzodiazepines.
Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction.
Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1.
Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome c release.
A mechanism of virulence: virulent Mycobacterium tuberculosis strain H37Rv, but not attenuated H37Ra, causes significant mitochondrial inner membrane disruption in macrophages leading to necrosis.
Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL.
Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences.
Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia.
Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation.
Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation.
In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila.
Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients.
Mitochondria from TRAIL-resistant prostate cancer cells are capable of responding to apoptotic stimuli.
A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release.
Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia-ischemia.
Mitochondrial DNA mutation and depletion increase the susceptibility of human cells to apoptosis.
Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity.
Early mitochondrial activation and cytochrome c up-regulation during apoptosis.
Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL).
Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells.
Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells.
Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases.
Superoxide radical-initiated apoptotic signalling pathway in selenite-treated HepG(2) cells: mitochondria serve as the main target.
Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore.
Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes.
Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors.
XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage.
Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-xL-overexpressing chemotherapy-resistant tumor cells.
Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis.
Purified photoproducts of merocyanine 540 trigger cytochrome C release and caspase 8-dependent apoptosis in human leukemia and melanoma cells.
Blocking cytochrome c activity within intact neurons inhibits apoptosis.
Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats.
A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen-presenting cells.
Huang X, Huang R, Gou S, Wang Z, Liao Z, Wang H
Bioconjugate chemistry 2016 Sep 21;27(9):2132-48
Bioconjugate chemistry 2016 Sep 21;27(9):2132-48
miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1.
Patel N, Garikapati KR, Ramaiah MJ, Polavarapu KK, Bhadra U, Bhadra MP
Life sciences 2016 Nov 1;164:60-70
Life sciences 2016 Nov 1;164:60-70
Curcumin conjugated with PLGA potentiates sustainability, anti-proliferative activity and apoptosis in human colon carcinoma cells.
Waghela BN, Sharma A, Dhumale S, Pandey SM, Pathak C
PloS one 2015;10(2):e0117526
PloS one 2015;10(2):e0117526
Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells.
Dhumale SS, Waghela BN, Pathak C
IUBMB life 2015 May;67(5):361-73
IUBMB life 2015 May;67(5):361-73
Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent.
Wang J, Schilling JM, Niesman IR, Headrick JP, Finley JC, Kwan E, Patel PM, Head BP, Roth DM, Yue Y, Patel HH
Anesthesiology 2014 Sep;121(3):538-48
Anesthesiology 2014 Sep;121(3):538-48
Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells.
Pradhan N, Pratheek BM, Garai A, Kumar A, Meena VS, Ghosh S, Singh S, Kumari S, Chandrashekar TK, Goswami C, Chattopadhyay S, Kar S, Maiti PK
Cell biology international 2014 Oct;38(10):1118-31
Cell biology international 2014 Oct;38(10):1118-31
Tailor-made designer helical peptides that induce mitochondrion-mediated cell death without necrosis.
Nogami K, Takahama K, Okushima A, Oyoshi T, Fujimoto K, Inouye M
Chembiochem : a European journal of chemical biology 2014 Nov 24;15(17):2571-6
Chembiochem : a European journal of chemical biology 2014 Nov 24;15(17):2571-6
Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells.
Kumar P, Rao GN, Pal BB, Pal A
The international journal of biochemistry & cell biology 2014 Aug;53:302-19
The international journal of biochemistry & cell biology 2014 Aug;53:302-19
Effects of CEES and LPS synergistically stimulate oxidative stress inactivates OGG1 signaling in macrophage cells.
Sagar S, Kumar P, Behera RR, Pal A
Journal of hazardous materials 2014 Aug 15;278:236-49
Journal of hazardous materials 2014 Aug 15;278:236-49
Resveratrol induces apoptosis via a Bak-mediated intrinsic pathway in human lung adenocarcinoma cells.
Zhang W, Wang X, Chen T
Cellular signalling 2012 May;24(5):1037-46
Cellular signalling 2012 May;24(5):1037-46
Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice.
Csak T, Dolganiuc A, Kodys K, Nath B, Petrasek J, Bala S, Lippai D, Szabo G
Hepatology (Baltimore, Md.) 2011 Jun;53(6):1917-31
Hepatology (Baltimore, Md.) 2011 Jun;53(6):1917-31
Synthesis and potential cytotoxic activity of new phenanthrylphenol-pyrrolobenzodiazepines.
Kamal A, Sreekanth K, Kumar PP, Shankaraiah N, Balakishan G, Ramaiah MJ, Pushpavalli SN, Ray P, Bhadra MP
European journal of medicinal chemistry 2010 Jun;45(6):2173-81
European journal of medicinal chemistry 2010 Jun;45(6):2173-81
Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction.
Douglas RM, Ryu J, Kanaan A, Del Carmen Rivero M, Dugan LL, Haddad GG, Ali SS
American journal of physiology. Cell physiology 2010 Jun;298(6):C1594-602
American journal of physiology. Cell physiology 2010 Jun;298(6):C1594-602
Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1.
Zall H, Weber A, Besch R, Zantl N, Häcker G
Molecular cancer 2010 Jun 24;9:164
Molecular cancer 2010 Jun 24;9:164
Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome c release.
Kumar P, Coltas IK, Kumar B, Chepeha DB, Bradford CR, Polverini PJ
Cancer research 2007 Feb 1;67(3):1193-202
Cancer research 2007 Feb 1;67(3):1193-202
A mechanism of virulence: virulent Mycobacterium tuberculosis strain H37Rv, but not attenuated H37Ra, causes significant mitochondrial inner membrane disruption in macrophages leading to necrosis.
Chen M, Gan H, Remold HG
Journal of immunology (Baltimore, Md. : 1950) 2006 Mar 15;176(6):3707-16
Journal of immunology (Baltimore, Md. : 1950) 2006 Mar 15;176(6):3707-16
Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL.
Meyer LH, Karawajew L, Schrappe M, Ludwig WD, Debatin KM, Stahnke K
Blood 2006 Jun 1;107(11):4524-31
Blood 2006 Jun 1;107(11):4524-31
Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences.
De Chiara G, Marcocci ME, Torcia M, Lucibello M, Rosini P, Bonini P, Higashimoto Y, Damonte G, Armirotti A, Amodei S, Palamara AT, Russo T, Garaci E, Cozzolino F
The Journal of biological chemistry 2006 Jul 28;281(30):21353-61
The Journal of biological chemistry 2006 Jul 28;281(30):21353-61
Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia.
Zhu C, Xu F, Wang X, Shibata M, Uchiyama Y, Blomgren K, Hagberg H
Journal of neurochemistry 2006 Feb;96(4):1016-27
Journal of neurochemistry 2006 Feb;96(4):1016-27
Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation.
Yamasaki E, Wada A, Kumatori A, Nakagawa I, Funao J, Nakayama M, Hisatsune J, Kimura M, Moss J, Hirayama T
The Journal of biological chemistry 2006 Apr 21;281(16):11250-9
The Journal of biological chemistry 2006 Apr 21;281(16):11250-9
Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation.
Arnoult D, Grodet A, Lee YJ, Estaquier J, Blackstone C
The Journal of biological chemistry 2005 Oct 21;280(42):35742-50
The Journal of biological chemistry 2005 Oct 21;280(42):35742-50
In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila.
Wong SL, Chen Y, Chan CM, Chan CS, Chan PK, Chui YL, Fung KP, Waye MM, Tsui SK, Chan HY
Biochemical and biophysical research communications 2005 Nov 18;337(2):720-9
Biochemical and biophysical research communications 2005 Nov 18;337(2):720-9
Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients.
Boden G, Homko C, Mozzoli M, Showe LC, Nichols C, Cheung P
Diabetes 2005 Mar;54(3):880-5
Diabetes 2005 Mar;54(3):880-5
Mitochondria from TRAIL-resistant prostate cancer cells are capable of responding to apoptotic stimuli.
Liang Y, Eid MA, Lewis RW, Kumar MV
Cellular signalling 2005 Feb;17(2):243-51
Cellular signalling 2005 Feb;17(2):243-51
A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release.
Mohr A, Zwacka RM, Debatin KM, Stahnke K
Cell death and differentiation 2004 Oct;11(10):1153-4
Cell death and differentiation 2004 Oct;11(10):1153-4
Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia-ischemia.
Zhu C, Wang X, Cheng X, Qiu L, Xu F, Simbruner G, Blomgren K
Brain research 2004 Jan 16;996(1):67-75
Brain research 2004 Jan 16;996(1):67-75
Mitochondrial DNA mutation and depletion increase the susceptibility of human cells to apoptosis.
Liu CY, Lee CF, Hong CH, Wei YH
Annals of the New York Academy of Sciences 2004 Apr;1011:133-45
Annals of the New York Academy of Sciences 2004 Apr;1011:133-45
Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity.
Colell A, García-Ruiz C, Lluis JM, Coll O, Mari M, Fernández-Checa JC
The Journal of biological chemistry 2003 Sep 5;278(36):33928-35
The Journal of biological chemistry 2003 Sep 5;278(36):33928-35
Early mitochondrial activation and cytochrome c up-regulation during apoptosis.
Chandra D, Liu JW, Tang DG
The Journal of biological chemistry 2002 Dec 27;277(52):50842-54
The Journal of biological chemistry 2002 Dec 27;277(52):50842-54
Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL).
Eid MA, Lewis RW, Kumar MV
Molecular cancer therapeutics 2002 Aug;1(10):831-40
Molecular cancer therapeutics 2002 Aug;1(10):831-40
Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells.
Bitzer M, Armeanu S, Prinz F, Ungerechts G, Wybranietz W, Spiegel M, Bernlöhr C, Cecconi F, Gregor M, Neubert WJ, Schulze-Osthoff K, Lauer UM
The Journal of biological chemistry 2002 Aug 16;277(33):29817-24
The Journal of biological chemistry 2002 Aug 16;277(33):29817-24
Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells.
Narvaez CJ, Welsh J
The Journal of biological chemistry 2001 Mar 23;276(12):9101-7
The Journal of biological chemistry 2001 Mar 23;276(12):9101-7
Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases.
Junn E, Mouradian MM
Journal of neurochemistry 2001 Jul;78(2):374-83
Journal of neurochemistry 2001 Jul;78(2):374-83
Superoxide radical-initiated apoptotic signalling pathway in selenite-treated HepG(2) cells: mitochondria serve as the main target.
Shen HM, Yang CF, Ding WX, Liu J, Ong CN
Free radical biology & medicine 2001 Jan 1;30(1):9-21
Free radical biology & medicine 2001 Jan 1;30(1):9-21
Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore.
Takuma K, Phuagphong P, Lee E, Mori K, Baba A, Matsuda T
The Journal of biological chemistry 2001 Dec 21;276(51):48093-9
The Journal of biological chemistry 2001 Dec 21;276(51):48093-9
Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes.
Wang GW, Klein JB, Kang YJ
The Journal of pharmacology and experimental therapeutics 2001 Aug;298(2):461-8
The Journal of pharmacology and experimental therapeutics 2001 Aug;298(2):461-8
Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors.
Maccarrone M, Lorenzon T, Bari M, Melino G, Finazzi-Agro A
The Journal of biological chemistry 2000 Oct 13;275(41):31938-45
The Journal of biological chemistry 2000 Oct 13;275(41):31938-45
XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage.
Datta R, Oki E, Endo K, Biedermann V, Ren J, Kufe D
The Journal of biological chemistry 2000 Oct 13;275(41):31733-8
The Journal of biological chemistry 2000 Oct 13;275(41):31733-8
Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-xL-overexpressing chemotherapy-resistant tumor cells.
Walczak H, Bouchon A, Stahl H, Krammer PH
Cancer research 2000 Jun 1;60(11):3051-7
Cancer research 2000 Jun 1;60(11):3051-7
Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis.
Maeno E, Ishizaki Y, Kanaseki T, Hazama A, Okada Y
Proceedings of the National Academy of Sciences of the United States of America 2000 Aug 15;97(17):9487-92
Proceedings of the National Academy of Sciences of the United States of America 2000 Aug 15;97(17):9487-92
Purified photoproducts of merocyanine 540 trigger cytochrome C release and caspase 8-dependent apoptosis in human leukemia and melanoma cells.
Pervaiz S, Seyed MA, Hirpara JL, Clément MV, Loh KW
Blood 1999 Jun 15;93(12):4096-108
Blood 1999 Jun 15;93(12):4096-108
Blocking cytochrome c activity within intact neurons inhibits apoptosis.
Neame SJ, Rubin LL, Philpott KL
The Journal of cell biology 1998 Sep 21;142(6):1583-93
The Journal of cell biology 1998 Sep 21;142(6):1583-93
Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats.
Fujimura M, Morita-Fujimura Y, Murakami K, Kawase M, Chan PH
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998 Nov;18(11):1239-47
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998 Nov;18(11):1239-47
A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen-presenting cells.
Jemmerson R, Johnson JG, Burrell E, Taylor PS, Jenkins MK
European journal of immunology 1991 Jan;21(1):143-51
European journal of immunology 1991 Jan;21(1):143-51
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