DPABH-02344

antibody from Creative Diagnostics

Targeting: SREBF1 bHLHd1, SREBP-1c, SREBP1, SREBP1a

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DPABH-02344

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-02344, RRID:AB_2507947

Product name

Rabbit Anti-Human SREBF1 Polyclonal antibody

Antibody type

Polyclonal

Description

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.

Reactivity

Human, Bovine, Chicken/Avian, Goat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

50 uL