F3

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]

Description

Coagulation factor III, tissue factor

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Intracellular, Membrane, Secreted to blood

Protein family

Cancer-related genes
Candidate cardiovascular disease genes
CD markers
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

1 (94529173 - 94541759)

Ensembl ID

ENSG00000117525  (ver. 103.38)

Orthologs

Mouse F3: ENSMUSG00000028128

UniProt

P13726

neXtProt

NX_P13726

Human splice variants
Mouse splice variants

Protein structure