DCABH-10841

antibody from Creative Diagnostics

Targeting: CAST

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DCABH-10841

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-10841, RRID:AB_2483730

Product name

Rabbit Anti-Human Calpastatin monoclonal antibody, clone TQ93

Antibody type

Monoclonal

Description

The calpain system has been detected in every vertebrate tissue examined, and has been suggested to play a regulatory role in cellular protein metabolism. This regulatory role may have important implications in platelet aggregation and pathologies associated with altered calcium homeostasis and protein metabolism such as ischemic cell injury and degenerative diseases. Inhibitors of calpain have been shown to block dexamethasone and low-level irradiation induced apoptosis in thymocytes suggesting that calpain has a regulatory or mechanistic role in apoptotic cell death. Calpastatin, a specific endogenous inhibitor of calpain, has a predicted molecular weight of ~77 kDa and an internal repeat of four homologous domains which allow it to inhibit multiple calpain molecules simultaneously. It functions by binding to calpain when calpain binds calcium. When calpastatin is subjected to proteolytic digestion, fragments of calpastatin as small as 15 kDa still retain inhibitory activity.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

TQ93

Storage

4°C, do not freeze