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TYROBP
Transmembrane immune signaling adaptor TYROBPDAP12, KARAP, PLO-SL, PLOSL
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
Top validated antibodies |
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| antibodies-online |  ABIN955408 |
3 references | Polyclonal |
WB
IHC
FC
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| Invitrogen Antibodies | MA5-34787 |
Monoclonal |
WB
ICC
IHC
FC
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| Novus Biologicals | NBP1-52376 |
1 references | Polyclonal |
EL
IHC
FC
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| R&D Systems | MAB5240 |
2 references | Monoclonal |
WB
FC
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| NovoPro Bioscience Inc. | 135032 |
Polyclonal |
WB
EL
IHC
FC
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