FURIN

gene product
FUR, PACE, PCSK3, SPC1
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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Invitrogen Antibodies
5 antibodies
Novus Biologicals
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Proteintech Group
2 antibodies
antibodies-online
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NovoPro Bioscience Inc.
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Enzo Life Sciences
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R&D Systems
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Boster Biological Technology
2 antibodies
HUABIO Research
1 antibody
Santa Cruz Biotechnology
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LifeSpan BioSciences, Inc.
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Biorbyt
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GeneTex
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Abnova Corporation
2 antibodies
OriGene
3 antibodies
Acris Antibodies GmbH
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St John's Laboratory
4 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Antibodies.com
1 antibody
Bioworld Technology, Inc
1 antibody
Everest Biotech
3 antibodies
NSJ Bioreagents
3 antibodies
Creative Biolabs
16 antibodies
Creative Diagnostics
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ABEOMICS Inc.
2 antibodies
Abgent
4 antibodies
Arigo
1 antibody
Aviva Systems Biology
1 antibody
Abbexa
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MyBioSource
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ProSci
2 antibodies
Leading Biology
4 antibodies
United States Biological
4 antibodies
RayBiotech, Inc.
2 antibodies
EMD Millipore
2 antibodies
Sigma-Aldrich
2 antibodies