WIPF1

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Description

WAS/WASL interacting protein family member 1

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (174559572 - 174682916)

Ensembl ID

ENSG00000115935  (ver. 103.38)

Orthologs

Mouse Wipf1: ENSMUSG00000075284

UniProt

O43516

neXtProt

NX_O43516

Human splice variants
Mouse splice variants

Protein structure