PLCD4

This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]

Description

Phospholipase C delta 4

Tissue specificity

Group enriched (retina, skeletal muscle)

Subcell location

Endoplasmic reticulum, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (218607855 - 218637184)

Ensembl ID

ENSG00000115556  (ver. 103.38)

Orthologs

Mouse Plcd4: ENSMUSG00000026173

UniProt

Q9BRC7

neXtProt

NX_Q9BRC7

Human splice variants
Mouse splice variants

Protein structure