MARCO

The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]

Description

Macrophage receptor with collagenous structure

Tissue specificity

Tissue enhanced (liver, lung, lymphoid tissue)

Subcell location

Golgi apparatus, Vesicles

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2:q14.2 (118942194 - 118994660)

Ensembl ID

ENSG00000019169  (ver. 103.38)

Orthologs

Mouse Marco: ENSMUSG00000026390

UniProt

Q9UEW3

neXtProt

NX_Q9UEW3

Human splice variants
Mouse splice variants