CHRM3

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

Description

Cholinergic receptor muscarinic 3

Tissue specificity

Tissue enhanced (brain, salivary gland)

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (239386565 - 239915452)

Ensembl ID

ENSG00000133019  (ver. 103.38)

Orthologs

Mouse Chrm3: ENSMUSG00000046159

UniProt

P20309

neXtProt

NX_P20309

Human splice variants
Mouse splice variants

Protein structure