DACH2

This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Description

Dachshund family transcription factor 2

Tissue specificity

Tissue enhanced (brain, epididymis, fallopian tube)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

X (86148451 - 86832604)

Ensembl ID

ENSG00000126733  (ver. 103.38)

Orthologs

Mouse Dach2: ENSMUSG00000025592

UniProt

Q96NX9

neXtProt

NX_Q96NX9

Human splice variants
Mouse splice variants

Protein structure