DDR2

This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]

Description

Discoidin domain receptor tyrosine kinase 2

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Actin filaments

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (162631373 - 162787405)

Ensembl ID

ENSG00000162733  (ver. 103.38)

Orthologs

Mouse Ddr2: ENSMUSG00000026674

UniProt

Q16832

neXtProt

NX_Q16832

Human splice variants
Mouse splice variants

Protein structure