AMM02501G

antibody from Leading Biology

Targeting: MAGED1 DLXIN-1, NRAGE

Western blot (Recommended by provider)

Antibody Data

Product number

AMM02501G

Provider

Leading Biology

Product name

MAGED1 Antibody (Center)

Antibody type

Monoclonal

Description

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds NGFR/p75NTR and antagonizes its association with NTRK1/TrkA, inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate TP53/p53 transcriptional activity and inhibit cell proliferation. Enhances TP53 phosphorylation and accumulation. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

1305CT862.157.127

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.