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Protein structure
GEMIN2
Gem nuclear organelle associated protein 2SIP1
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]
Top validated antibodies |
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| Proteintech Group |  21672-1-AP |
4 references | Polyclonal |
WB
EL
IP
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| OriGene | AP31198PU-N |
Polyclonal |
WB
EL
ICC
IHC
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| NovoPro Bioscience Inc. | 127986 |
Polyclonal |
WB
EL
ICC
IHC
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| Affinity Biosciences | BF0592 |
Monoclonal |
WB
EL
IHC
FC
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| Cusabio Biotech Co., Ltd | CSB-PA021329LA01HU |
Polyclonal |
WB
EL
ICC
IP
|
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