CREB3L3

This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Description

CAMP responsive element binding protein 3 like 3

Tissue specificity

Group enriched (intestine, liver)

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

19 (4153631 - 4173054)

Ensembl ID

ENSG00000060566  (ver. 103.38)

Orthologs

Mouse Creb3l3: ENSMUSG00000035041

UniProt

Q68CJ9

neXtProt

NX_Q68CJ9

Human splice variants
Mouse splice variants

Protein structure