Tissue expression
Cell line expression
Protein structure
GPC3
Glypican 3DGSX, OCI-5, SDYS, SGB, SGBS, SGBS1
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Top validated antibodies |
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antibodies-online | ABIN1107403 | 2 references | Monoclonal |
WB
EL
ICC
IHC
FC
|
|
Invitrogen Antibodies | MA5-17083 | 2 references | Monoclonal |
WB
ICC
IHC
FC
OA
|
|
R&D Systems | AF2119 | 3 references | Polyclonal |
WB
ICC
IHC
FC |
|
Novus Biologicals | AF2119 | 4 references | Polyclonal |
WB
ICC
IHC
FC |
|
Acris Antibodies GmbH | AM06776PU-N | Monoclonal |
WB
EL
ICC
IHC
FC
|
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