CR1

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020]

Description

Complement C3b/C4b receptor 1 (Knops blood group)

Tissue specificity

Tissue enhanced (adipose tissue, lymphoid tissue)

Predicted location

Membrane

Protein family

Blood group antigen proteins
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (207496147 - 207641765)

Ensembl ID

ENSG00000203710  (ver. 103.38)

Orthologs

Mouse Cr1l: ENSMUSG00000016481

UniProt

P17927

neXtProt

NX_P17927

Human splice variants
Mouse splice variants

Protein structure