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BACE1
Beta-secretase 1BACE
This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]
Top validated antibodies |
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| Proteintech Group |  12807-1-AP |
23 references | Polyclonal |
WB
EL
IP
IHC
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| LSBio | LS-C377 |
Polyclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | PA1-757 |
35 references | Polyclonal |
WB
ICC
OA
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| Abnova Corporation | H00023621-M01 |
Monoclonal |
WB
EL
IHC
PLA
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| R&D Systems | MAB931-100 |
4 references | Monoclonal |
WB
IHC
FC
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