COIL

The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

Description

Coilin

Tissue specificity

Tissue enriched (testis)

Subcell location

Nucleoplasm, Nucleoli, Nuclear bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (56938199 - 56961050)

Ensembl ID

ENSG00000121058  (ver. 103.38)

Orthologs

Mouse Coil: ENSMUSG00000033983

UniProt

P38432

neXtProt

NX_P38432

Human splice variants
Mouse splice variants

Protein structure