PPARD

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

Description

Peroxisome proliferator activated receptor delta

Tissue specificity

Low tissue specificity

Predicted location

Intracellular

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Chromosome

6 (35342558 - 35428191)

Ensembl ID

ENSG00000112033  (ver. 103.38)

Orthologs

Mouse Ppard: ENSMUSG00000002250

UniProt

Q03181

neXtProt

NX_Q03181

Human splice variants
Mouse splice variants

Protein structure