MED19

The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Description

Mediator complex subunit 19

Tissue specificity

Low tissue specificity

Subcell location

Nuclear bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

11 (57703714 - 57712323)

Ensembl ID

ENSG00000156603  (ver. 103.38)

Orthologs

Mouse Med19: ENSMUSG00000027080

UniProt

A0JLT2

neXtProt

NX_A0JLT2

Human splice variants
Mouse splice variants

Protein structure