CEMIP2

This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]

Description

Cell migration inducing hyaluronidase 2

Tissue specificity

Tissue enhanced (parathyroid gland, placenta)

Subcell location

Vesicles, Plasma membrane, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (71683366 - 71816690)

Ensembl ID

ENSG00000135048  (ver. 103.38)

Orthologs

Mouse Cemip2: ENSMUSG00000024754

UniProt

Q9UHN6

neXtProt

NX_Q9UHN6

Human splice variants
Mouse splice variants

Protein structure