641401

antibody from BioLegend

Targeting: FOS AP-1, c-fos

Western blot (Recommended by provider)

Antibody Data

Product number

641401

Provider

BioLegend

Proper citation

BioLegend Cat#641401, RRID:AB_2106632

Product name

Purified anti-c-Fos

Antibody type

Polyclonal

Antigen

c-Fos

Description

The c-fos protein, also known as FBJ murine viral (v-fos) oncogene homolog , is a 62 kD cellular oncogene. The c-fos protein contains a bZIP region with a DNA-binding domain and a leucine zipper domain. Together with c-jun, c-jun proteins form the heterodimeric AP-1 complex that binds to the TRE elements of cellular and viral genes including collagenase, interleukin 2, stromelysin, SV40 and polyoma among others. c-fos is expressed in a variety of normal adult tissues and has been implicated as a critical transcription factor for skeletal formation and maintenance. This transcription factor is modified by phosphorylation by a number of upstream kinases and has been shown to interact with a variety of other proteins involved in transcriptional regulation. c-fos has been implicated in the development of fibrous bone dysplasia and osteosarcoma. The c-fos protein has been shown to interact with a variety of other proteins including c-jun, TFIID, NCOA2, NFAT1, CHOP, ELK1, SRC1, and ETS1. The Poly6244 antibody recognizes human, rat, and mouse c-fos and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Vial size

25 µl

Storage

Upon receipt, store at -20°C.