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Protein structure
CSK
C-terminal Src kinaseThe protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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| Proteintech Group |  17720-1-AP |
3 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Novus Biologicals | H00001445-M01 |
1 references | Monoclonal |
WB
EL
IP
IHC
BN
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| Abnova Corporation | H00001445-M01 |
1 references | Monoclonal |
WB
EL
IP
IHC
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| Atlas Antibodies | HPA028425 |
1 references | Polyclonal |
WB
ICC
IHC
|
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| Invitrogen Antibodies | 17720-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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