PRCC

This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle. [provided by RefSeq, Aug 2010]

Description

Proline rich mitotic checkpoint control factor

Tissue specificity

Low tissue specificity

Subcell location

Nuclear speckles

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (156750610 - 156800815)

Ensembl ID

ENSG00000143294  (ver. 103.38)

Orthologs

Mouse Prcc: ENSMUSG00000004895

UniProt

Q92733

neXtProt

NX_Q92733

Human splice variants
Mouse splice variants

Protein structure