PLA2G12B

The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Description

Phospholipase A2 group XIIB

Tissue specificity

Tissue enhanced (intestine, kidney, liver)

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

10 (72934762 - 72954806)

Ensembl ID

ENSG00000138308  (ver. 103.38)

Orthologs

Mouse Pla2g12b: ENSMUSG00000009646

UniProt

Q9BX93

neXtProt

NX_Q9BX93

Human splice variants
Mouse splice variants

Protein structure